883232-69-7Relevant academic research and scientific papers
Silver-Catalyzed [3+2] Cycloaddition of Azomethine Ylides with Isocyanides for Imidazole Synthesis
Hu, Zhongyan,Dong, Jinhuan,Xu, Xianxiu
, p. 3585 - 3591 (2017)
A silver-catalyzed aerobic oxidative [3+2] cycloaddition of azomethine ylides with aryl or heteroaryl isocyanides has been developed. The reaction represents a novel protocol for the efficient and practical synthesis of 1,2-diarylimidazoles bearing a broad range of substituents in good to excellent yields under mild conditions. The practicability of this cycloaddition was shown by a gram-scale synthesis and a double cycloaddition for the construction of highly conjugated polyarylimidazole systems. (Figure presented.).
Azomethine-isocyanide [3+2] cycloaddition to imidazoles promoted by silver and DBU
Huang, Xiaoshan,Cong, Xuefeng,Mi, Pengbing,Bi, Xihe
, p. 3858 - 3861 (2017)
A new silver-promoted [3+2] cycloaddition of azomethine ylides with isocyanides has been described. The methodology provides an efficient and modular approach to 1,2,4-trisubstituted imidazoles of vital bioactive molecules and atypical antipsychotics analogues.
Imidazole Compound
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Page/Page column 32, (2010/11/29)
An imidazole compound of the formula: wherein Ring A is benzene or a heterocyclic ring; G is alkylthio, alkylsulfonyl, optionally substituted phenyl, or optionally substituted heterocyclic ring group, etc.; Ring C is imidazole; R1 is carbamoyl, etc.; R2 is cyano, nitro, hydroxyl, an alkoxy, a halogen, carboxy, an alkoxycarbonyl, carbamoyl, amino, an alkyl, etc.; m is 0 to 2; and R4 is hydrogen, an alkyl, etc., or a pharmaceutically acceptable salt thereof, is a large conductance calcium-activated K channel opener useful for treatment of pollakiuria, urinary incontinence, etc.
