883242-52-2

Basic information

• Product Name: 3',4'-dibenzyloxy-6-hydroxyflavone
• Synonyms: 3',4'-dibenzyloxy-6-hydroxyflavone
• CAS NO: 883242-52-2
• Molecular Weight: 450.491
• Mol File: 883242-52-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3',4'-dibenzyloxy-6-hydroxyflavone(CAS DataBase Reference)
• NIST Chemistry Reference: 3',4'-dibenzyloxy-6-hydroxyflavone(883242-52-2)
• EPA Substance Registry System: 3',4'-dibenzyloxy-6-hydroxyflavone(883242-52-2)

Safety Data

• Hazardous Substances Data: 883242-52-2(Hazardous Substances Data)

Upstream product

• 174398-83-5 ethyl 3,4-bis(benzyloxy)benzoate 
• 3943-89-3 Ethyl protocatechuate 
• 99-50-3 3,4-Dihydroxybenzoic acid 
• 883242-49-7 1-(3,4-bis-benzyloxyphenyl)-3-(2,5-dihydroxyphenyl)propane-1,3-dione 

Downstream Products

• 883242-65-7 3',4'-dibenzyloxy-6-[3-(tert-butylamino)-2-hydroxypropoxy]flavone 
• 883242-78-2 3',4'-dihydroxy-6-[3-(tert-butylamino)-2-hydroxy-propoxy]flavone 
• 883242-56-6 3',4'-dibenzyloxy-6-(2,3-epoxypropoxy)flavone 

Relevant articles and documents

Flavone-based novel antidiabetic and antidyslipidemic agents

The hybrid congeners 62-90 of 6- and 7-hydroxyflavones with aminopropanol have been synthesized and evaluated for their antidiabetic activity in sucrose-challenged low-dosed streptozotocin (STZ)-induced diabetic rats and db/db mice. The optical enantiomers 70a, 70b, 90a, and 90b of two congeners 70 and 90 exhibiting consistent antidiabetic and antidyslipidemic activities were also prepared, and their antidiabetic activity results indicate its association mainly with S isomers. These compounds also lower cholesterol and TG profiles while improving high-density lipoprotein cholesterol to CHOL ratio in db/db mice. The bioavailability of compound 70 and its isomer varies between 27 and 29% whereas that of the more polar compound 90a is poor as determined in rat by oral and intraperitoneal administrations. Published 2012 by the American Chemical Society.