88329-46-8Relevant academic research and scientific papers
Application of Organolithium and Related Reagents in Synthesis, Part XII. Synthesis of Phenyl- and Pyridylpyridopyridazinones and their Derivatives
Epsztajn, J.,Brzezinski, J. Z.,Czeh, K.
, p. 549 - 558 (1993)
The preparation of the pyridazinones 10a, 10b, 11a, 11b, and 12a, 12b from the ketoamides 7, 8, and 9 and hydrazine hydrate is described.It was found that from the ketoamides 8b and 9b in addition to the expected pyridopyridazinones 11b and 12b also aminopyridopyridazines 14 and 15 were formed and that ketoamide 7b gave exclusively aminopyridopyridazine 13.The pyridopyridazinones 10b, 11b, and 12b were alkylated with alkyl iodides. Key words: Pyridinecarboxamides; lithiation; benzoylpyridinecarboxamides; pyridinecarbonylpyridinecarboxamides; pyridopyridazinones; aminopyridopyridazines.
Studies on the 4-benzoylpyridine-3-carboxamide entity as a fragment model of the Isoniazid-NAD adduct
Broussy, Sylvain,Bernardes-Genisson, Vania,Gornitzka, Heinz,Bernadou, Jean,Meunier, Bernard
, p. 666 - 669 (2007/10/03)
An ortho-metallatkm-electrophilic substitution sequence was employed as a key step to build the 4-benzoylpyridine framework. It was found that 4-benzoylpyridine-3-carboxamide and an N-pyridyl alkylated derivative both exist in a unique cyclized hemiamidal
APPLICATIONS of ORGANOLITHIUM and RELATED REAGENTS in SYNTHESIS. Part IV. A General Study of the Reaction of N,N-Dialkylpyridinecarboxamides with Lithium Diisopropylamide
Epsztajn, Jan,Brzezinski, Jacek Z.,Jozwiak, Andrzej
, p. 401 - 441 (2007/10/02)
The reactions of the N,N-dialkylpyridinecarboxamides (1), (2) and (3) derived from picolinic, nicotinic and isonicotinic acids with lithium diisopropylamides have been examied.It is shown that in contrast with N,N-diethylpyridinecarboxamides (1a), (2a) an
THE DUAL BEHAVIOUR OF N,N-DIALKYLPYRIDYLCARBOXYLIC AMIDES IN THE REACTION WITH LITHIUM DIISOPROPYLAMIDE
Epsztajn, Jan,Bieniek, Adam,Brzezinski, Jacek Z.,Jozwiak, Andrzej
, p. 4735 - 4738 (2007/10/02)
The dual behaviour of N,N-diisopropylpyridylcarboxylic amides in the reaction with iPr2NLi depending upon temperature and structure of a given amide, is described.
