883458-69-3Relevant academic research and scientific papers
Application of a 6π-1-azatriene electrocyclization strategy to the total synthesis of the marine sponge metabolite ageladine A and biological evaluation of synthetic analogues
Meketa, Matthew L.,Weinreb, Steven M.,Nakao, Yoichi,Fusetani, Nobuhiro
, p. 4892 - 4899 (2008/02/05)
(Chemical Equation Presented) A 12-step synthesis of the angiogenesis inhibitory marine metabolite ageladine A is reported. The key steps include a 6π-1-azatriene electrocyclization for formation of the pyridine ring and a Suzuki-Miyaura coupling of N-Boc
Total synthesis of ageladine A, an angiogenesis inhibitor from the marine sponge Agelas nakamurai
Meketa, Matthew L.,Weinreb, Steven M.
, p. 1443 - 1446 (2007/10/03)
A 12-step total synthesis of the tricyclic heteroaromatic marine metabolite ageladine A has been achieved using a 6π-azaelectrocyclization and a Suzuki-Miyaura coupling of N-Boc-pyrrole-2-boronic acid with a chloropyridine as key steps.
