883458-68-2Relevant academic research and scientific papers
Application of a 6π-1-azatriene electrocyclization strategy to the total synthesis of the marine sponge metabolite ageladine A and biological evaluation of synthetic analogues
Meketa, Matthew L.,Weinreb, Steven M.,Nakao, Yoichi,Fusetani, Nobuhiro
, p. 4892 - 4899 (2008/02/05)
(Chemical Equation Presented) A 12-step synthesis of the angiogenesis inhibitory marine metabolite ageladine A is reported. The key steps include a 6π-1-azatriene electrocyclization for formation of the pyridine ring and a Suzuki-Miyaura coupling of N-Boc
A convergent total synthesis of the marine sponge alkaloid ageladine A via a strategic 6π-2-azatriene electrocyclization
Meketa, Matthew L.,Weinreb, Steven M.
, p. 9112 - 9119 (2008/02/09)
A second generation total synthesis of the marine sponge metabolite ageladine A utilizing a biogenetically inspired 6π-2-azaelectrocyclization of triene 34 as the key step is performed to construct the imidazopyridine core of the metabolite.
Total synthesis of ageladine A, an angiogenesis inhibitor from the marine sponge Agelas nakamurai
Meketa, Matthew L.,Weinreb, Steven M.
, p. 1443 - 1446 (2007/10/03)
A 12-step total synthesis of the tricyclic heteroaromatic marine metabolite ageladine A has been achieved using a 6π-azaelectrocyclization and a Suzuki-Miyaura coupling of N-Boc-pyrrole-2-boronic acid with a chloropyridine as key steps.
