883458-68-2Relevant academic research and scientific papers
A convergent total synthesis of the marine sponge alkaloid ageladine A via a strategic 6π-2-azatriene electrocyclization
Meketa, Matthew L.,Weinreb, Steven M.
, p. 9112 - 9119 (2008/02/09)
A second generation total synthesis of the marine sponge metabolite ageladine A utilizing a biogenetically inspired 6π-2-azaelectrocyclization of triene 34 as the key step is performed to construct the imidazopyridine core of the metabolite.
Application of a 6π-1-azatriene electrocyclization strategy to the total synthesis of the marine sponge metabolite ageladine A and biological evaluation of synthetic analogues
Meketa, Matthew L.,Weinreb, Steven M.,Nakao, Yoichi,Fusetani, Nobuhiro
, p. 4892 - 4899 (2008/02/05)
(Chemical Equation Presented) A 12-step synthesis of the angiogenesis inhibitory marine metabolite ageladine A is reported. The key steps include a 6π-1-azatriene electrocyclization for formation of the pyridine ring and a Suzuki-Miyaura coupling of N-Boc
Total synthesis of ageladine A, an angiogenesis inhibitor from the marine sponge Agelas nakamurai
Meketa, Matthew L.,Weinreb, Steven M.
, p. 1443 - 1446 (2007/10/03)
A 12-step total synthesis of the tricyclic heteroaromatic marine metabolite ageladine A has been achieved using a 6π-azaelectrocyclization and a Suzuki-Miyaura coupling of N-Boc-pyrrole-2-boronic acid with a chloropyridine as key steps.
