88346-65-0Relevant academic research and scientific papers
Structure-Activity Relationships among Di- and Tetramine Disulfides Related to Benextramine
Alvarez, M.,Granados, R.,Mauleon, D.,Rosell, G.,Salas, M.,et al.
, p. 1186 - 1193 (2007/10/02)
The synthesis and irreversible α-blocking activity in the rat vas deferens of a series of tetra- and diamine disulfides 2-38, structural analogues of benextramine (BHC), are described. All compounds containing a central cystamine moiety displayed an irreversible α-adrenergic blockade at concentrations ranging from 10-4 to 6*10-6 M. Potency was increased in cystamines N,N'-disubstituted with 6-aminohexyl groups, especially when the outer nitrogen atoms bear arylalkyl substituents or are enclosed in a ring. However, N,N,N',N'-tetrasubstituted cystamines were poor blockers. Structural specificity in the outer portion of the tetramine disulfide is low, since many types of substituents gave rise to potent α-blockers. Even replacement of the outer amines with nonbasic ethers or amides was observed to maintain irreversible α-blockade.
Synthesis of 1,2,3,4-tetrahydroquinazoline derivatives as potential alpha-adrenergic blocking agents
Granados,Alvarez,Valls,Salas
, p. 1271 - 1275 (2007/10/02)
The synthesis of N,N'-bis[6-(1,2,3,4-tetrahydro-3-quinazolidyl)hexyl)cystamine (1) and 3-(6-aminohexyl)-1,2,3,4-tetrahydroquinazoline (II) are described. Compound I is obtained by condensation of o-nitrobenzoyl chloride with 3-(6-aminohexyl)-1,3-thiazolid
