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Usage

Uses

Used in Pharmaceutical Industry:
1-(TRIFLUOROMETHYLCYCLOPROPYL)BENZENE is used as a chemical intermediate for the synthesis of novel drugs. Its unique properties allow for the development of pharmaceuticals with enhanced efficacy and selectivity, contributing to the advancement of treatments for various diseases and conditions.
Used in Agrochemical Industry:
In the agrochemical field, 1-(TRIFLUOROMETHYLCYCLOPROPYL)BENZENE is utilized as a key component in the creation of new pesticides and herbicides. Its reactive nature and structural features enable the design of more effective and targeted agrochemicals, aiming to improve crop protection and yield.
Used in Materials Science:
1-(TRIFLUOROMETHYLCYCLOPROPYL)BENZENE is employed as a building block for the development of advanced materials with unique properties. Its incorporation into material compositions can lead to the creation of innovative products with applications in various sectors, such as electronics, coatings, and composites.
Overall, 1-(TRIFLUOROMETHYLCYCLOPROPYL)BENZENE's broad range of applications in pharmaceuticals, agrochemicals, and materials science underscores its significance as a versatile and valuable compound in modern organic synthesis and product development.

Upstream product

• 6120-95-2 1-phenyl-1-cyclopropane carboxylic acid 

Downstream Products

• 1227160-19-1 4-[1-(trifluoromethyl)cyclopropyl]benzonitrile 
• 1227160-18-0 1-bromo-4-(1-(trifluoromethyl)cycloprop-1-yl)benzene 
• 1227160-30-6 5-(5-methyl-1H-pyrazol-3-yl)-3-{4-[1-(trifluoromethyl)cyclopropyl]phenyl}-1,2,4-oxadiazole 
• 1227160-17-9 N'-hydroxy-4-[1-(trifluoromethyl)cyclopropyl]benzenecarboximide amide 
• 1347581-62-7 5-[1-(3-Bromobenzyl)-5-methyl-1H-pyrazol-3-yl]-3-{4-[1-(trifluoromethyl)cyclopropyl]phenyl}-1,2,4-oxadiazole 
• 1418297-04-7 4-[1-(trifluoromethyl)cyclopropyl]benzaldehyde 
• 1418296-66-8 1-cyclopropyl-4-[4-({3-[(Z)-1-fluoro-2-{4-[1-(trifluoromethyl)cyclopropyl]phenyl}vinyl]-5-methyl-1H-pyrazol-1-yl}methyl)pyridin-2-yl]piperazine 
• 1418297-03-6 3-[(Z)-1-fluoro-2-{4-[1-(trifluoromethyl)cyclopropyl]phenyl}vinyl]-5-methyl-1H-pyrazole 
• 1418296-31-7 C₂₂H₁₈ClF₄N₃ 
• 1034047-31-8 4-(1-(trifluoromethyl)cyclopropyl)benzene-1-sulfonyl chloride 

Relevant academic research and scientific papers

A NOVEL PROCESS FOR THE SYNTHESIS OF 1-ARYL-1-TRIFLUOROMETHYLCYCLOPROPANES

The present invention relates to a process for the manufacturing of 1-aryl-1-trifluoromethylcyclopropanes, which serve as intermediates for the manufacturing of calcium T channel blockers of the general formula (A) which are described in WO 2015/186056.

1,3-γ-Silyl-elimination in electron-deficient cationic systems

Placement of an electron-withdrawing trifluoromethyl group (-CF 3) at a putative cationic centre enhances γ-silyl neighbouring-group participation (NGP). In stark contrast to previously studied γ-silyl-substituted systems, the preferred reaction pathway is 1,3-γ-silyl elimination, giving ring closure over solvent substitution or alkene formation. The scope of this cyclopropanation reaction is explored for numerous cyclic and acyclic examples, proving this method to be a viable approach to preparing CF3-substituted cyclopropanes and bicyclic systems, both containing quaternary centres. Rate-constants, kinetic isotope effects, and quantum mechanical calculations provided evidence for this enhancement and further elaborated the disparity in the reaction outcome between these systems and previously studied γ-silyl systems.