1227160-18-0

Basic information

• Product Name: 1-Bromo-4-(1-trifluoromethyl-cyclopropyl)-benzene
• Synonyms: 1-Bromo-4-(1-trifluoromethyl-cyclopropyl)-benzene;1-(4-Bromophenyl)-1-(trifluoromethyl)cyclopropane;1-Bromo-4-[1-(trifluoromethyl)cycloprop-1-yl]benzene
• CAS NO: 1227160-18-0
• Molecular Formula: C₁₀H₈BrF₃
• Molecular Weight: 265
• Mol File: 1227160-18-0.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-Bromo-4-(1-trifluoromethyl-cyclopropyl)-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Bromo-4-(1-trifluoromethyl-cyclopropyl)-benzene(1227160-18-0)
• EPA Substance Registry System: 1-Bromo-4-(1-trifluoromethyl-cyclopropyl)-benzene(1227160-18-0)

Safety Data

• Hazardous Substances Data: 1227160-18-0(Hazardous Substances Data)

Usage

Description

1-Bromo-4-(1-trifluoromethyl-cyclopropyl)-benzene is an organic compound characterized by its unique molecular structure, featuring a bromine atom attached to a benzene ring, with a cyclopropyl group substituted by a trifluoromethyl group. 1-Bromo-4-(1-trifluoromethyl-cyclopropyl)-benzene is known for its potential applications in the pharmaceutical and chemical industries due to its versatile chemical properties.

Uses

1. Used in Pharmaceutical Industry:
1-Bromo-4-(1-trifluoromethyl-cyclopropyl)-benzene is used as a reactant in the synthesis of a potent, selective T-type calcium channel blocker. 1-Bromo-4-(1-trifluoromethyl-cyclopropyl)-benzene serves as a crucial intermediate in the development of new drug candidates for the treatment of generalized epilepsies. Its unique structure allows for the modulation of calcium channel activity, which can help in managing the neurological symptoms associated with epilepsy.
2. Used in Chemical Synthesis:
1-Bromo-4-(1-trifluoromethyl-cyclopropyl)-benzene can also be utilized as a building block in the synthesis of various other organic compounds. Its bromine atom and trifluoromethyl-substituted cyclopropyl group make it a valuable starting material for the creation of a wide range of molecules with potential applications in different industries, such as agrochemicals, materials science, and specialty chemicals.

Upstream product

• 345965-52-8 1-(4-bromophenyl)cyclopropanecarboxylic acid 
• 136476-20-5 1-bromo-4-(3,3,3-trifluoroprop-1-en-2-yl)benzene 
• 1431616-40-8 3-(4-bromophenyl)-3-(trifluoromethyl)-4,5-dihydro-3H-pyrazole 
• 883547-73-7 1-phenyl-1-(trifluoromethyl)cyclopropane 
• 887144-97-0 Togni's reagent 
• 122243-28-1 2‐(4‐bromophenyl)‐1,1,1‐trifluoropropan‐2‐ol 
• 16184-89-7 4'-bromo-2,2,2-trifluoroacetophenone 

Downstream Products

• 1431616-26-0 6-(4-(1-(trifluoromethyl)cyclopropyl)phenyl)nicotinonitrile 
• 1431616-45-3 4-(1-(trifluoromethyl)cyclopropyl)benzoyl chloride 
• 1431616-29-3 4-(1-(trifluoromethyl)cyclopropyl)-N-(6-(trifluoromethyl)pyridin-3-yl)benzamide 
• 1431616-31-7 N-(6-cyanopyridin-3-yl)-4-(1-(trifluoromethyl)cyclopropyl)benzamide 
• 1431616-32-8 N-(4-cyanophenyl)-4-(1-(trifluoromethyl)cyclopropyl)benzamide 
• 1431616-33-9 4-(1-(trifluoromethyl)cyclopropyl)-N-(4-(trifluoromethyl)phenyl)benzamide 
• 1431616-36-2 5-fluoro-2-(4-(1-(trifluoromethyl)cyclopropyl)phenyl)pyridine 
• 1431616-38-4 4-(4-(1-(trifluoromethyl)cyclopropyl)phenyl)picolinonitrile 
• 1431616-41-9 4-(1-(trifluoromethyl)cyclopropyl)phenylboronic acid 
• 1418128-91-2 4-((1-trifluoromethyl)cycloprop-1-yl)benzoic acid 
• 1418297-04-7 4-[1-(trifluoromethyl)cyclopropyl]benzaldehyde 

Relevant articles and documents

Redox-Neutral Photocatalytic Cyclopropanation via Radical/Polar Crossover

A benchtop stable, bifunctional reagent for the redox-neutral cyclopropanation of olefins has been developed. Triethylammonium bis(catecholato)iodomethylsilicate can be readily prepared on multigram scale. Using this reagent in combination with an organic photocatalyst and visible light, cyclopropanation of an array of olefins, including trifluoromethyl- and pinacolatoboryl-substituted alkenes, can be accomplished in a matter of hours. The reaction is highly tolerant of traditionally reactive functional groups (carboxylic acids, basic heterocycles, alkyl halides, etc.) and permits the chemoselective cyclopropanation of polyolefinated compounds. Mechanistic interrogation revealed that the reaction proceeds via a rapid anionic 3-exo-tet ring closure, a pathway consistent with experimental and computational data.

Decarboxylative Trifluoromethylation of Aliphatic Carboxylic Acids

Herein we disclose an efficient method for the conversion of carboxylic acids to trifluoromethyl groups via the combination of photoredox and copper catalysis. This transformation tolerates a wide range of functionality including heterocycles, olefins, al

SUBSTITUTED 1H-PYRROLOPYRIDINONE DERIVATIVES AS KINASE INHIBITORS

The present invention provides novel substituted 1H-Pyrrolopyridinone derivatives of formula (1) as protein kinase inhibitors, in which R1, R2, R3, R4, R5, R6 and 'p' have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention in diseases or disorder, in particular their use in diseases or disorder where there is an advantage in inhibiting kinase enzyme, more particularly BTK enzyme. The present invention also provides methods for synthesizing and administering the kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor.