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1227160-18-0

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1227160-18-0 Usage

Uses

1-Bromo-4-(1-(trifluoromethyl)cyclopropyl)benzene is used as a reactant in the synthesis of a potent, selective T-type calcium channel blocker as drug candidate for treatment of generalized epilepsies.

Check Digit Verification of cas no

The CAS Registry Mumber 1227160-18-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,7,1,6 and 0 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1227160-18:
(9*1)+(8*2)+(7*2)+(6*7)+(5*1)+(4*6)+(3*0)+(2*1)+(1*8)=120
120 % 10 = 0
So 1227160-18-0 is a valid CAS Registry Number.

1227160-18-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-bromo-4-[1-(trifluoromethyl)cyclopropyl]benzene

1.2 Other means of identification

Product number -
Other names 1-Bromo-4-(1-trifluoromethyl-cyclopropyl)-benzene

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1227160-18-0 SDS

1227160-18-0Relevant articles and documents

Redox-Neutral Photocatalytic Cyclopropanation via Radical/Polar Crossover

Phelan, James P.,Lang, Simon B.,Compton, Jordan S.,Kelly, Christopher B.,Dykstra, Ryan,Gutierrez, Osvaldo,Molander, Gary A.

supporting information, p. 8037 - 8047 (2018/07/03)

A benchtop stable, bifunctional reagent for the redox-neutral cyclopropanation of olefins has been developed. Triethylammonium bis(catecholato)iodomethylsilicate can be readily prepared on multigram scale. Using this reagent in combination with an organic photocatalyst and visible light, cyclopropanation of an array of olefins, including trifluoromethyl- and pinacolatoboryl-substituted alkenes, can be accomplished in a matter of hours. The reaction is highly tolerant of traditionally reactive functional groups (carboxylic acids, basic heterocycles, alkyl halides, etc.) and permits the chemoselective cyclopropanation of polyolefinated compounds. Mechanistic interrogation revealed that the reaction proceeds via a rapid anionic 3-exo-tet ring closure, a pathway consistent with experimental and computational data.

Decarboxylative Trifluoromethylation of Aliphatic Carboxylic Acids

Kautzky, Jacob A.,Wang, Tao,Evans, Ryan W.,Macmillan, David W. C.

supporting information, p. 6522 - 6526 (2018/05/25)

Herein we disclose an efficient method for the conversion of carboxylic acids to trifluoromethyl groups via the combination of photoredox and copper catalysis. This transformation tolerates a wide range of functionality including heterocycles, olefins, al

SUBSTITUTED 1H-PYRROLOPYRIDINONE DERIVATIVES AS KINASE INHIBITORS

-

, (2014/09/03)

The present invention provides novel substituted 1H-Pyrrolopyridinone derivatives of formula (1) as protein kinase inhibitors, in which R1, R2, R3, R4, R5, R6 and 'p' have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention in diseases or disorder, in particular their use in diseases or disorder where there is an advantage in inhibiting kinase enzyme, more particularly BTK enzyme. The present invention also provides methods for synthesizing and administering the kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor.

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