883554-93-6Relevant articles and documents
Chemoselective Probe Containing a Unique Bioorthogonal Cleavage Site for Investigation of Gut Microbiota Metabolism
Garg, Neeraj,Conway, Louis P.,Ballet, Caroline,Correia, Mario S. P.,Olsson, Frida K. S.,Vujasinovic, Miroslav,L?hr, J.-Matthias,Globisch, Daniel
supporting information, p. 13805 - 13809 (2018/09/25)
While metabolites derived from gut microbiota metabolism have been linked to disease development in the human host, the chemical tools required for their detailed analysis and the discovery of biomarkers are limited. A unique and multifunctional chemical probe for mass spectrometric analysis, which contains p-nitrocinnamyloxycarbonyl as a new bioorthogonal cleavage site has been designed and synthesized. Coupled to magnetic beads, this chemical probe allows for straightforward extraction of metabolites from human samples and release under mild conditions. This isolation from the sample matrix results in significantly reduced ion suppression, an increased mass spectrometric sensitivity, and facilitates the detection of metabolites in femtomole quantities. The chemoselective probe was applied to the analysis of human fecal samples, resulting in the discovery of four metabolites previously unreported in this sample type and confirmation of the presence of medically relevant gut microbiota-derived metabolites.
Decoupling fluorescence and photochromism in bifunctional azo derivatives for bulk emissive structures
Jacquart, Aurelie,Williams, Rene M.,Brouwer, Albert M.,Ishow, Elena
scheme or table, p. 3706 - 3720 (2012/05/04)
Bifunctional molecules that combine independent push-pull fluorophores and azo photochromes have been synthesized to create fluorescent structures upon light-induced migration in neat thin films. Their photochromic and emissive properties have been systematically investigated and interpreted in light of those of the corresponding model compounds. Fluorescence lifetimes and photoisomerization and fluorescence quantum yields have been determined in toluene solution. Kinetic analyses of the femtosecond transient absorption spectra reveal that the fluorophores evolve in a few picoseconds into a distorted intramolecular charge-transfer excited state, strongly stabilized in energy. Radiative relaxation to the ground state occurred competitively with the energy-transfer process to the azo moiety. Introduction of a 10 A-long rigid and nonconjugated bridge between the photoactive units efficiently inhibits the energy transfer while it imparts enhanced free volume, which favors photoactivated molecular migration in the solid state. Copyright
PRODUCTS FROM NITRATION OF 3,5-SUBSTITUTED BENZOIC ACIDS
Nekhoroshev, A. A.,Sevbo, D. P.,Ginzburg, O. A.
, p. 313 - 317 (2007/10/02)
During the nitration of 3,5-substituted benzoic acids by a nitrating mixture one isomer is formed if one of the substituents is an acetylamino group.
