88356-97-2

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 15452-52-5 1-methanesulfonyl-4-(2-nitro-propenyl)-benzene 

Downstream Products

• 1396341-68-6 C₁₀H₁₁BrO₃S 
• 593959-13-8 5-(4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-ylamine 
• 593958-72-6 N-[5-(4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide 
• 481679-94-1 C₃₀H₃₁NO₅S₂ 
• 144296-73-1 6-methyl-5-(4-methylsulphonylphenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide 
• 97143-03-8 6-methyl-5-(4-methylsulphonylphenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile 
• 144296-78-6 6-methyl-5-(4-methylsulphonylphenyl)-2-oxo-3-amino-1,2-dihydropyridine 
• 144296-62-8 4-dimethylamino-3-(4-methylsulphonylphenyl)-3-buten-2-one 

Relevant academic research and scientific papers

Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway

Using a parallel synthesis approach to target a non-conserved region of the PI3K catalytic domain a pan-PI3K inhibitor 1 was elaborated to provide alpha, delta and gamma isoform selective Class I PI3K inhibitors 21, 24, 26 and 27. The compounds had good cellular activity and were selective against protein kinases and other members of the PI3K superfamily including mTOR and DNA-PK.

1,2-Diarylindole derivatives, processes for their preparation and their uses in therapeutics

The present invention relates to the derivatives of the formula STR1 and to their use in therapeutics, especially as drugs with anti-inflammatory and analgesic properties.