88356-97-2

Basic information

• Product Name: 2-Propanone, 1-[4-(methylsulfonyl)phenyl]-
• CAS NO: 88356-97-2
• Molecular Formula: C10H12O3S
• Molecular Weight: 212.26500
• Mol File: 88356-97-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-Propanone, 1-[4-(methylsulfonyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propanone, 1-[4-(methylsulfonyl)phenyl]-(88356-97-2)
• EPA Substance Registry System: 2-Propanone, 1-[4-(methylsulfonyl)phenyl]-(88356-97-2)

Safety Data

• Hazardous Substances Data: 88356-97-2(Hazardous Substances Data)

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 15452-52-5 1-methanesulfonyl-4-(2-nitro-propenyl)-benzene 

Downstream Products

• 481679-94-1 C₃₀H₃₁NO₅S₂ 
• 1396341-68-6 C₁₀H₁₁BrO₃S 
• 593959-13-8 5-(4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-ylamine 
• 593958-72-6 N-[5-(4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide 
• 144296-73-1 6-methyl-5-(4-methylsulphonylphenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide 
• 97143-03-8 6-methyl-5-(4-methylsulphonylphenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile 
• 144296-78-6 6-methyl-5-(4-methylsulphonylphenyl)-2-oxo-3-amino-1,2-dihydropyridine 
• 144296-62-8 4-dimethylamino-3-(4-methylsulphonylphenyl)-3-buten-2-one 

Relevant articles and documents

Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway

Using a parallel synthesis approach to target a non-conserved region of the PI3K catalytic domain a pan-PI3K inhibitor 1 was elaborated to provide alpha, delta and gamma isoform selective Class I PI3K inhibitors 21, 24, 26 and 27. The compounds had good cellular activity and were selective against protein kinases and other members of the PI3K superfamily including mTOR and DNA-PK.

5-PHENYLTHIAZOLE DERIVATIVES AND THEIR USE AS PI3 KINASE INHIBITORS

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