593959-13-8

Basic information

• Product Name: 2-Thiazolamine, 4-methyl-5-[4-(methylsulfonyl)phenyl]-
• CAS NO: 593959-13-8
• Molecular Formula: C11H12N2O2S2
• Molecular Weight: 268.36
• Mol File: 593959-13-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Thiazolamine, 4-methyl-5-[4-(methylsulfonyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiazolamine, 4-methyl-5-[4-(methylsulfonyl)phenyl]-(593959-13-8)
• EPA Substance Registry System: 2-Thiazolamine, 4-methyl-5-[4-(methylsulfonyl)phenyl]-(593959-13-8)

Safety Data

• Hazardous Substances Data: 593959-13-8(Hazardous Substances Data)

Upstream product

• 88356-97-2 1-(4-methanesulfonyl-phenyl)-propan-2-one 
• 459-57-4 4-fluorobenzaldehyde 
• 15452-52-5 1-methanesulfonyl-4-(2-nitro-propenyl)-benzene 
• 5398-77-6 para-methanesulfonylbenzaldehyde 
• 1396341-68-6 C₁₀H₁₁BrO₃S 
• 17356-08-0 thiourea 
• 593958-72-6 N-[5-(4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide 
• 79-08-3 bromoacetic acid 

Downstream Products

• 593958-72-6 N-[5-(4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide 
• 593959-14-9 1-ethyl-3-[5-(4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-urea 

Relevant articles and documents

Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway

Using a parallel synthesis approach to target a non-conserved region of the PI3K catalytic domain a pan-PI3K inhibitor 1 was elaborated to provide alpha, delta and gamma isoform selective Class I PI3K inhibitors 21, 24, 26 and 27. The compounds had good cellular activity and were selective against protein kinases and other members of the PI3K superfamily including mTOR and DNA-PK.

5-PHENYLTHIAZOLE DERIVATIVES AND USE AS PI3 KINASE INHIBITORS

Compounds of Formula I in free or salt form, wherein R1,R2,R3,R4, and R5, have the meanings as indicated in the specification, are useful for treating diseases mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.