88365-41-7Relevant academic research and scientific papers
Synthesis of α-Cyanoenamines by Cyanation of α-Bromoimmonium Bromides and Dehydrobromination of β-Bromo-α-(dialkylamino)nitriles
Kimpe, Norbert De,Verhe', Roland,Buyck, Laurent De,Schamp, Niceas
, p. 3846 - 3857 (2007/10/02)
The reaction of α-bromoimmonium bromides 4 with potassium cyanide in dimethylformamide gave rise to β-bromo-α-(dialkylamino)nitriles 5, which were dehydrobrominated in various base solvent systems to afford (E)- and (Z)-α-cyanoenamines 2.An adaption of a previously published preparation of α-cyanoenamines starting from aldehydes via enamines led to an improved, efficient and fast synthesis of the title compounds.
