883715-40-0

Basic information

• Product Name: 4,4,5,5-TETRAMETHYL-2-(2-METHYL-4-NITROPHENYL)-1,3,2-DIOXABOROLANE
• Synonyms: 4,4,5,5-TETRAMETHYL-2-(2-METHYL-4-NITROPHENYL)-1,3,2-DIOXABOROLANE;2-Methyl-4-nitrophenylboronic acid pinacol ester;1,3,2-Dioxaborolane, 4,4,5,5-tetramethyl-2-(2-methyl-4-nitrophenyl)-
• CAS NO: 883715-40-0
• Molecular Formula: C₁₃H₁₈BNO₄
• Molecular Weight: 263.1
• Mol File: 883715-40-0.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 379.6°C at 760 mmHg
• Flash Point: 183.4°C
• Appearance: /
• Density: 1.13g/cm³
• Vapor Pressure: 1.26E-05mmHg at 25°C
• Refractive Index: 1.514
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4,4,5,5-TETRAMETHYL-2-(2-METHYL-4-NITROPHENYL)-1,3,2-DIOXABOROLANE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4,5,5-TETRAMETHYL-2-(2-METHYL-4-NITROPHENYL)-1,3,2-DIOXABOROLANE(883715-40-0)
• EPA Substance Registry System: 4,4,5,5-TETRAMETHYL-2-(2-METHYL-4-NITROPHENYL)-1,3,2-DIOXABOROLANE(883715-40-0)

Safety Data

• Hazardous Substances Data: 883715-40-0(Hazardous Substances Data)

Usage

General Description

4,4,5,5-TETRAMETHYL-2-(2-METHYL-4-NITROPHENYL)-1,3,2-DIOXABOROLANE is a chemical compound with the molecular formula C14H19BNO4. It is a boron-containing organic compound that is used in organic synthesis, particularly in the formation of carbon-carbon and carbon-heteroatom bonds. 4,4,5,5-TETRAMETHYL-2-(2-METHYL-4-NITROPHENYL)-1,3,2-DIOXABOROLANE has potential applications in medicinal chemistry and as a reagent in organic reactions. Its structure contains a dioxaborolane ring, which gives it unique chemical properties and reactivity. 4,4,5,5-TETRAMETHYL-2-(2-METHYL-4-NITROPHENYL)-1,3,2-DIOXABOROLANE is a valuable tool in the development of new chemical compounds and materials.

InChI:InChI=1/C13H18BNO4/c1-9-8-10(15(16)17)6-7-11(9)14-18-12(2,3)13(4,5)19-14/h6-8H,1-5H3

Upstream product

• 7149-70-4 2-bromo-5-nitrotoluene 
• 73183-34-3 bis(pinacol)diborane 
• 99-52-5 2-methyl-4-nitro-benzenamine 

Downstream Products

• 1030832-68-8 2-(2-(bromomethyl)-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 377780-72-8 2-(2-(bromomethyl)phenyl)-4,4,5,5,-tetramethyl-1,3,2-dioxaborolane 
• 1447933-45-0 trimethyl-[2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-quaternaryammonium bromide 
• 1447933-48-3 trimethyl-[2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5-nitrobenzyl]-quaternaryammonium bromide 
• 1447933-52-9 C₁₀H₁₆BN₂O₄⁽¹⁺⁾*Br^(1-) 
• 25240-59-9 pinacolboronic acid 
• 772-33-8 Koshlands reagent I 
• 39224-61-8 2-hydroxy-5-nitrobenzyl alcohol 
• 875816-94-7 1,3-dihydro-5-nitro-1-hydroxy-2,1-benzoxaborole 
• 1447933-59-6 3-(bromomethyl)-5-nitrobenzene-1,2-diol 
• 76-09-5 2,3-dimethyl-2,3-butane diol 
• 195062-59-0 2-methylphenylboronic acid pinacol ester 
• 1565857-72-8 trimethyl(3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)stannane 
• 1877-77-6 3-aminobenzenemethanol 

Relevant articles and documents

PERK INHIBITING COMPOUNDS

Provided herein are compounds of formula (I), compositions, and methods useful for inhibiting PERK and for treating related conditions, diseases, and disorders.

Synthesis of Amino- and Hydroxymethyl Benzoxaboroles: Prominent Scaffolds for Further Functionalization

Herein, we describe the development of a short, simple, and efficient synthesis of amino- and hydroxymethyl-substituted benzoxaboroles. The key step in our strategy was the early stage incorporation of the boron by the borylation of an aniline. The formed boronates were then elaborated to the final products in two additional steps, usually in good yields. The synthetic sequence was amenable to be performed on a preparative scale and 4-amino benzoxaborole 4b and 6-hydroxymethyl benzoxaborole 10c have been prepared, without any significant decrease in the overall yield. The amino and hydroxymethyl present at the molecules are useful for further elaboration and/or conjugation to bioactive molecules and therefore we believe that this method should be useful in the development of new compounds for Medicinal Chemistry.

Synthesis of trimethylstannyl arylboronate compounds by sandmeyer-type transformations and their applications in chemoselective cross-coupling reactions

A synthetic method based on Sandmeyer-type reactions to access both tin- and boron-substituted arenes from nitroaniline derivatives is described. This transformation can be applied to the synthesis of a series of functionalized trimethylstannyl arylboronates. In addition, the chemoselective reaction of the Stille and Suzuki-Miyaura cross-coupling reactions is explored, and a series of m- and p-terphenyl derivatives have been synthesized by conducting consecutive one-pot Stille and Suzuki-Miyaura cross-coupling reactions.