88372-34-3

Usage

Uses

Used in Pharmaceutical Industry:
3,3-diphenyl-1-(piperazin-1-yl)propan-1-one is used as a building block for the synthesis of pharmaceuticals for its potential pharmacological activities, particularly as an analgesic and anesthetic agent.
Used in Chemical Industry:
3,3-diphenyl-1-(piperazin-1-yl)propan-1-one is used as a precursor in the synthesis of novel drugs and chemical compounds, contributing to the development of new organic compounds with various applications.

Upstream product

• 24353-19-3 4P₇₈ 
• 143210-47-3 4-(3,3-Diphenyl-propionyl)-piperazine-1-carbaldehyde 
• 37089-77-3 3,3-diphenylpropanoyl chloride 
• 606-83-7 3,3-Diphenylpropionic acid 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 727360-84-1 4-(3,3-diphenyl-propionyl)-piperazine-1-carboxylic Acid Tert-butyl Ester 

Downstream Products

• 122678-65-3 1,1-diethyl-4-(3,3-diphenyl-propionyl)-piperazinium; iodide 
• 143817-22-5 [4-(3,3-Diphenyl-propionyl)-piperazin-1-yl]-thiazol-5-yl-acetonitrile 
• 746575-76-8 3,3-Diphenyl-1-[4-(pyridine-4-carbonyl)-piperazin-1-yl]-propan-1-one 
• 143817-19-0 [4-(3,3-Diphenyl-propionyl)-piperazin-1-yl]-(1-methyl-1H-indol-3-yl)-acetonitrile 
• 143817-20-3 [4-(3,3-Diphenyl-propionyl)-piperazin-1-yl]-(1-methyl-1H-pyrrol-3-yl)-acetonitrile 
• 143817-17-8 3-{Cyano-[4-(3,3-diphenyl-propionyl)-piperazin-1-yl]-methyl}-benzonitrile 
• 143817-15-6 [4-(3,3-Diphenyl-propionyl)-piperazin-1-yl]-(3-trifluoromethyl-phenyl)-acetonitrile 
• 143817-10-1 1-(3,3-diphenylpropionyl)-4-(3-pyridylsulfonyl)piperazine 
• 143817-14-5 [4-(3,3-Diphenyl-propionyl)-piperazin-1-yl]-(3-nitro-phenyl)-acetonitrile 
• 143817-16-7 (3-Chloro-phenyl)-[4-(3,3-diphenyl-propionyl)-piperazin-1-yl]-acetonitrile 
• 143817-18-9 (4-Dimethylamino-phenyl)-[4-(3,3-diphenyl-propionyl)-piperazin-1-yl]-acetonitrile 
• 143817-09-8 1-[4-(1-Oxy-pyridine-4-carbonyl)-piperazin-1-yl]-3,3-diphenyl-propan-1-one 
• 727360-85-2 [4-(3,3-diphenyl-propionyl)-piperazin-1-yl]-acetic Acid Ethyl Ester 
• 143817-21-4 [4-(3,3-Diphenyl-propionyl)-piperazin-1-yl]-(1-methyl-1H-pyrrol-2-yl)-acetonitrile 

Relevant academic research and scientific papers

Substituted piperizines for the treatment of pain

The present invention is directed to the use of substituted piperizine compounds represented by Formula I, for the treatment of pain, including acute pain, chronic pain, cancer pain, visceral pain, inflammatory pain, neuropathic pain, post-herpetic neural

ISOXAZOLE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS

Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted N-type or T-type calcium channel activity are disclosed. Specifically, a series of isoxazole containing compounds are disclosed of the general formula (1) where Z is N or CHNR3 and (Ar1)2CR4 is optionally substituted benzhydryl.

Preferentially substituted calcium channel blockers

Certain piperazine substituted compounds are described which are useful in altering calcium channel activity.

(Pyridylcyanomethyl)piperazines as orally active PAF antagonists

A series of (pyridylcyanomethyl)piperazines was prepared and evaluated for PAF-antagonist activity. Compounds were tested in vitro in a PAF-induced platelet aggregation assay and in vivo in a PAF-induced hypotension test in normotensive rats. Oral activity was ascertained through a PAF-induced mortality test in mice. The main structure-activity trends of the series were established. Activity was mainly found in four skeletons: 1-acyl-4-(3- pyridylcyanomethyl)-piperazine, 1-acyl-4-(4-pyridylcyanomethyl)piperazine, 1- acyl-4-(3-pyridylcyanomethyl)piperidine, and 1-acyl-4-cyano-4-(3- pyridylamino)piperidine. The acyl substituents, diphenylacetyl and 3,3- diphenylpropionyl, provided the most active compounds, and the introduction of an amine or hydroxy group in the 3,3-diphenylpropionyl substituent led to further improvement in oral activity. As a result, three of the most active compounds (100, 114, and 115) have been selected for further pharmacological development.