883738-54-3

Basic information

• Product Name: given name is incorrect
• Synonyms: given name is incorrect
• CAS NO: 883738-54-3
• Molecular Weight: 444.274
• Mol File: 883738-54-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: given name is incorrect(CAS DataBase Reference)
• NIST Chemistry Reference: given name is incorrect(883738-54-3)
• EPA Substance Registry System: given name is incorrect(883738-54-3)

Safety Data

• Hazardous Substances Data: 883738-54-3(Hazardous Substances Data)

Upstream product

• 15307-79-6 diclofenac sodium 
• 175609-21-9 5-(bromomethyl)benzofuroxan 

Relevant articles and documents

Synthesis and pharmacological characterization of a novel nitric oxide-releasing diclofenac derivative containing a benzofuroxan moiety

1-Oxy-benzo[1,2,5]oxadiazol-5-ylmethyl [2-(2,6-dichloro-phenylamino)-phenyl]-acetate, a new diclofenac derivative bearing a benzofuroxan heterocyclic moiety in its structure, was prepared by the reaction of sodium diclofenac and 5-bromomethyl-benzo[1,2,5]oxadiazole 1-oxide. Pharmacological characterization of this modified diclofenac maintained the anti-inflammatory activity similar to its parent compound assayed in vitro and in vivo. The ulcerogenic properties of native diclofenac were not observed with this modified compound, despite the inhibition of prostaglandin E2 gastric content. The better gastric tolerability seems to be related to nitric oxide release ability.