88376-63-0

Basic information

• Product Name: 3-(4-Fluorophenyl)-1-adamantanecarboxamide
• CAS NO: 88376-63-0
• Molecular Weight: 273.35
• Mol File: 88376-63-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(4-Fluorophenyl)-1-adamantanecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-Fluorophenyl)-1-adamantanecarboxamide(88376-63-0)
• EPA Substance Registry System: 3-(4-Fluorophenyl)-1-adamantanecarboxamide(88376-63-0)

Safety Data

• Hazardous Substances Data: 88376-63-0(Hazardous Substances Data)

Upstream product

• 88358-11-6 3-(4-Fluorophenyl)-1-adamantanecarboxylic acid 
• 21816-08-0 3-bromoadamantane-1-carboxylic acid 

Downstream Products

• 117077-69-7 3-(4-Fluorophenyl)-1-adamantanemethylamine 

Relevant articles and documents

Synthesis of 3-Aryl-1-adamantanemethylamines

Friedel-Crafts alkylations of fluorobenzene, thioanisole, and thiophene with 3-bromo-1-adamantanecarboxylic acid are reported.Various Lewis acids (AlCl3, FeCl3, ZnCl2, SnCl4) served as effective catalysts for these substitution reactions.The products were 3-aryl-1-adamantanecarboxylic acids.Substitution took place in fluorobenzene and thioanisole at the para position and in thiophene at positions 2 and 3.These acids were reacted with phosphorus pentachloride and then ammonia to form amides which were reduced by lithium aluminum hydride to provide the corresponding3-aryl-1-adamantanemethylamines.