883793-06-4Relevant academic research and scientific papers
Ruthenium-catalyzed C6-propenylation reactions of substituted pyridine derivatives: Directed and direct C-H activation
Goriya, Yogesh,Ramana, Chepuri V.
, p. 13288 - 13292,5 (2012)
One stone, two birds: Aryl pyridine derivatives in the presence of allyl bromide and a catalytic amount of [{Ru(p-cymene)Cl2}2] undergo an unexpected direct C6-propenylation reaction of the pyridine moiety. A one-pot one-catalyst three-component reaction involving sequential and selective direct and directed C-H activation reactions was also developed (see scheme).
Radical C?H Acylation of Nitrogen Heterocycles Induced by an Aerobic Oxidation of Aldehydes
Paul, Subhasis,Bhakat, Manotosh,Guin, Joyram
supporting information, p. 3154 - 3160 (2019/08/30)
An aerobic radical approach for the synthesis of unsymmetrical heteroaryl ketones is described herein. The reaction involves cross-dehydrogenative coupling between aldehydes and heteroaromatic bases with molecular oxygen (O2). The key aspect of the method is the generation of reactive acyl radical via homolytic activation of aldehyde C?H bond using O2 as the sole oxidant. The reaction has a good substrate scope with respect to aldehydes and functionalized nitrogen heterocycles. Based on our mechanistic studies, a radical chain pathway is suggested for the reaction. A synthetic application of the method is demonstrated in the formal synthesis of natural alkaloid (±) angustureine.
