Ruthenium-catalyzed C6-propenylation reactions of substituted pyridine derivatives: Directed and direct C-H activation

Article abstract of DOI:10.1002/chem.201202379

One stone, two birds: Aryl pyridine derivatives in the presence of allyl bromide and a catalytic amount of [{Ru(p-cymene)Cl₂}₂] undergo an unexpected direct C6-propenylation reaction of the pyridine moiety. A one-pot one-catalyst three-component reaction involving sequential and selective direct and directed C-H activation reactions was also developed (see scheme).