88384-26-3

Upstream product

• 881-83-4 1-(4-bromophenyl)-3-(N,N-dimethylamino)propan-1-one hydrochloride 
• 99-90-1 para-bromoacetophenone 
• 2138-34-3 1-(4-bromo-phenyl)-3-dimethylamino-propan-1-one 

Downstream Products

• 941320-36-1 dimethyl-{3-phenoxy-3-[4-(4-piperidin-1-yl-but-1-ynyl)-phenyl]-propyl}-amine 
• 941320-34-9 [3-(4-bromo-phenyl)-3-phenoxy-propyl]-dimethyl-amine 
• 941320-35-0 C₁₈H₁₉NOBrF₃ 
• 88384-29-6 Carbonic acid 1-(4-bromo-phenyl)-3-dimethylamino-propyl ester phenyl ester; hydrochloride 

Relevant academic research and scientific papers

Synthesis and pharmacological evaluation of 3-aryl-3-azolylpropan-1-amines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors

A series of 3-aryl-3-azolylpropan-1-amines was prepared and screened for its capability of inhibiting monoamine reuptake. Analogs with nanomolar potency, good human in vitro microsomal stability, and low drug-drug interaction potential were described. In

SUBSTITUTED PHENYL PROPYL AMINES AS HISTAMINE H3 RECEPTOR AND SEROTONIN TRANSPORTER MODULATORS

Certain substituted phenyl propyl amine compounds are histamine H3 receptor and/or serotonin transporter modulators useful in the treatment of histamine H3 receptor- and/or serotonin-mediated diseases.

Synthesis and biological evaluation of diamine-based histamine H3 antagonists with serotonin reuptake inhibitor activity

The synthesis and structure-activity relationships of a series of novel phenoxyphenyl diamine derivatives with affinity for both the histamine H3 receptor and the serotonin transporter is described.

Duloxetine (Cymbalta), a dual inhibitor of serotonin and norepinephrine reuptake.

A series of naphthalenyloxy-arylpropylamines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake. One member of this series, duloxetine (Cymbalta) has proven to be effective in clinical trials for the treatment of depression.