883857-29-2

Upstream product

• 2627-86-3 (S)-1-phenyl-ethylamine 
• 171598-25-7 (+)-(R_P)-methylphenylvinylphosphine oxide 
• 123492-27-3 [2-((S)-Methyl-phenyl-phosphinoyl)-ethyl]-((R)-1-phenyl-ethyl)-amine 
• 89438-78-8 (-)-(S_P)-methylphenylvinylphosphine oxide 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 185855-09-8 (S)-1,2:5,6-di-O-cyclohexylidene-D-glucose methyl phenyl phosphinate 
• 5761-97-7 methyl(phenyl)phosphinic chloride 
• 6389-79-3 methyl methylphenylphosphinate 
• 352007-12-6 (S_P,R_C)-PhCH(Me)NH(CH₂)2PPhMe 

Relevant academic research and scientific papers

Practical synthesis of chiral vinylphosphine oxides by direct nucleophilic substitution. Stereodivergent synthesis of aminophosphine ligands

A practical synthesis of optically pure alkylphenylvinylphosphine oxides is described, utilizing a nucleophilic displacement at phosphorus to install the vinyl moiety. The products were used to prepare classes of P-stereogenic aminophosphine (PN) and aminohydroxyphosphine (PNO) ligands. Stereocontrol can be exerted at various stages of the synthesis, to provide specific combinations of chirality in the final product. The effect of the stereogenic phosphorus and match-mismatch of chiralities of PNO ligands were examined in the asymmetric ruthenium-catalyzed hydrogen transfer reduction of three aryl ketones.

P-chiral β-aminophosphine oxides vs. β-aminophosphines as auxiliaries for ruthenium catalysed enantioselective transfer hydrogenation of arylketones

Enantiopure P-chiral β-aminophosphine oxides and the corresponding β-aminophosphines have been synthesised and used as chiral auxiliaries in ruthenium catalysed asymmetric transfer hydrogenation of arylketones producing optically active alcohols up to 80%