883864-92-4

Usage

Uses

Used in Pharmaceutical Industry:
1,5-NAPHTHYRIDINE-2-CARBOXALDEHYDE is used as a reactant in the preparation of [1,5]naphthyridine azothiazolones, which are CDK1 antiproliferative agents. These agents have potential applications in the development of treatments for various diseases, including cancer, by inhibiting cell proliferation and promoting cell cycle arrest.

Upstream product

• 80287-53-2 5-Amino-2-methylpyridine 
• 7675-32-3 2-methyl-[1,5]naphthyridine 

Downstream Products

• 1521138-37-3 2-((4-(4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)-1,5-naphthyridine 
• 1521138-42-0 1-(4-((1,5-naphthyridin-2-yl)methoxy)phenyl)-2-(pyridin-4-yl)ethanone 

Relevant academic research and scientific papers

RADIOLABELED PDE10A LIGANDS

Compounds of formula (I) are disclosed Compounds of formula (I) are useful in treating conditions and disorders prevented by or ameliorated by PDE10A ligands. Radiolabeled compounds of formula (I) are also useful as diagnostic tools as PDE10A positron emi

CERTAIN TRIAZOLOPYRIDINES AND TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR

Provided are certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use therefor.

HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF

Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes

1,5-naphthyridine azolinone

1,5-Naphthyridine azolinone derivatives are disclosed. These compounds are inhibitors of CDK1 and are useful as antiproliferative agents, such as anti-cancer agents.