883893-69-4Relevant academic research and scientific papers
Mild ruthenium-catalyzed intermolecular alkyne cyclotrimerization
Das, Sanjoy K.,Roy, Rene
, p. 4015 - 4018 (1999)
Grubbs' catalyst [(PCy3)2Cl2Ru=CHPh, 7] was shown for the first time to be an effective catalyst for the mild intermolecular cyclotrimerization of terminal alkynes (1-6). The reaction is general and the isomeric trisubstit
H-BPin/KOtBu Promoted Activation of Cobalt Salt to a Heterotopic Catalyst for Highly Selective Cyclotrimerization of Alkynes
Song, Shuo,Li, Chuhan,Liu, Tianfen,Zhang, Panke,Wang, Xiaoming
supporting information, p. 6925 - 6930 (2021/09/14)
A mixture of HBPin with KOtBu was found to activate cobalt salt to form a heterotopic cobalt species that is highly active for catalytic intermolecular trimerization of alkynes. This protocol affords 1,2,4-regioisomers in good yields with high regioselectivities under mild conditions. These salient features, together with the operational simplicity and high efficiency, as well as obviating the use of any costly and/or air sensitive ligands, renders the protocol promising for practical applications.
Iron-catalyzed regioselective cyclotrimerization of alkynes to benzenes
Gawali, Suhas Shahaji,Gunanathan, Chidambaram
, p. 139 - 149 (2019/01/03)
We report the synthesis and characterization of simple di(aminomethyl)pyridine ligated iron-pincer complexes, which catalyzed the regioselective [2+2+2] cyclotrimerization of terminal aryl and alkyl alkynes to provide the 1,2,4-trisubstituted benzene molecules. Interestingly, internal alkynes also exhibited similar cyclization and resulted in hexa-substituted benzene compounds. Increased steric bulk on pincer ligands diminished the selectivity for cycloaddition. Cyclotrimerization reactions proceeded at room temperature upon activation of catalyst by a Grignard reagent. EPR studies indicated thermally induced spin crossover effect in catalyst.
Exploiting guanidine as a ligand in cobalt-catalyzed alkyne cyclotrimerizations
Eichman, Chad C.,Bragdon, Jason P.,Stambuli, James P.
supporting information; experimental part, p. 1109 - 1112 (2011/06/20)
The synthesis of polysubstituted arenes is accomplished via the regioselective cyclotrimerization of alkynes utilizing a guanidine-ligated cobalt catalyst. Georg Thieme Verlag Stuttgart - New York.
Remarkable drug-release enhancement with an elimination-based AB3 self-immolative dendritic amplifier
Sagi, Amit,Segal, Ehud,Satchi-Fainaro, Ronit,Shabat, Doron
, p. 3720 - 3727 (2008/02/07)
Self-immolative dendritic prodrugs, activated through a single catalytic reaction by a specific enzyme, could offer significant advantages in inhibition of tumor growth relative to monomeric prodrug, especially if the targeted or secreted enzyme exists at
A highly practical instant catalyst for cyclotrimerization of alkynes to substituted benzenes
Saino, Naoko,Amemiya, Fumihiro,Tanabe, Emi,Kase, Kouki,Okamoto, Sentaro
, p. 1439 - 1442 (2007/10/03)
A 2-(2,6-diisopropylphenyl)iminomethylpyridine (1a)/CoCl 2·6H2O/Zn reagent has been developed as an effective instant catalyst for the intra- and intermolecular cyclotrimerization of alkynes to substituted benzenes, making the method
