883899-83-0Relevant academic research and scientific papers
Convergent synthesis of the right-hand segment of ciguatoxin
Hamajima, Akinari,Isobe, Minoru
, p. 1205 - 1208 (2007/10/03)
A convergent synthesis of the right-hand half of ciguatoxin (the HIJKLM ring system) has been achieved with complete stereocontrol in the introduction of the stereocenters on the eight-membered I ring. Key steps are Sonogashira coupling, dicobalt complexation, intramolecular conjugate addition, and hydrogenation of an endo-olefin to provide the 39-α-methyl group.
