883907-97-9

Upstream product

• 5390-04-5 pent-1-yn-5-ol 
• 61362-77-4 5-[tert-butyldimethylsilyloxy]pent-1-yne 
• 158897-35-9 (E)-tert-butyl((5-iodo-4-methylpent-4-en-1-yl)oxy)dimethylsilane 
• 77364-02-4 (E)-4-methyl-6-phenyl-4-hexen-1-ol 
• 1025798-50-8 (E)-(3S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-1-((S)-4-isopropyl-2-thioxo-thiazolidin-3-yl)-8-methyl-10-phenyl-dec-8-en-1-one 
• 883907-96-8 (E)-(R)-3-Hydroxy-1-((R)-4-isopropyl-2-thioxo-thiazolidin-3-yl)-6-methyl-8-phenyl-oct-6-en-1-one 
• 934672-43-2 (E)-4-methyl-6-phenylhex-4-enal 
• 345895-27-4 E-1-(tert-butyldimethylsilyloxy)-4-methyl-6-phenyl-4-hexene 

Downstream Products

• 1026961-20-5 2,2-Dimethyl-propionic acid (E)-(1S,3R)-1-[(E)-(R)-6-acetoxy-2-(tert-butyl-diphenyl-silanyloxy)-4-methyl-hex-4-enyl]-3-(tert-butyl-dimethyl-silanyloxy)-6-methyl-8-phenyl-oct-6-enyl ester 

Relevant academic research and scientific papers

Synthesis of the C1-C5 and C6-C24 fragments of the RNA polymerase inhibitors ripostatin A and B

The enantioselective synthesis of the C1-C5 and C6-C24 fragments of the ripostatins utilize a Negishi coupling, two Nagao acetate aldol reactions followed by a Denmark vinylogous aldol reaction and Stille couplings as key C-C bond forming steps. Georg Thi