88392-91-0

Upstream product

• 52787-14-1 methyl 4-(2-methoxy-2-oxoethyl)benzoate 
• 75-03-6 ethyl iodide 

Downstream Products

• 88392-95-4 4-amino-4-deoxy-10-ethyl-10-carbomethoxy-8,10-dideazapteroate 
• 88393-02-6 (S)-2-{4-[1-(2,4-Diamino-pyrido[3,2-d]pyrimidin-6-ylmethyl)-propyl]-benzoylamino}-pentanedioic acid diethyl ester 
• 88393-05-9 (S)-2-{4-[1-(2,4-Diamino-pyrido[3,2-d]pyrimidin-6-ylmethyl)-propyl]-benzoylamino}-pentanedioic acid 
• 88392-99-8 4-amino-4-deoxy-10-ethyl-8,10-dideazapteroic acid 
• 272779-25-6 4-[1-(2,4-diamino-pteridin-6-ylmethyl)-1-methoxycarbonyl-propyl]-benzoic acid 
• 272779-24-5 4-[1-(2,4-diamino-pteridin-6-ylmethyl)-1-methoxycarbonyl-propyl]-benzoic acid methyl ester 

Relevant academic research and scientific papers

Analogues of the potent nonpolyglutamatable antifolate N(α)-(4-amino-4- deoxypteroyl)-N(δ)-hemiphthaloyl-L-ornithine (PT523) with modifications in the side chain, p-aminobenzoyl moiety, or 9,10-bridge: Synthesis and in vitro antitumor activity

Seven N(α)-(4-amino-4-deoxypteroyl)-N(δ)-hemiphthaloyl-L-ornithine (2, PT523) analogues were synthesized by modifications of the literature synthesis of the corresponding AMT (1) analogues and were tested as inhibitors of tumor cell growth. In growth assa

Synthesis and antifolate properties of 10-alkyl-8,10-dideazaminopterins

The synthesis of 10-alkyl analogues of the potent antitumor agent 8,10-dideazaminopterin is described. Alkylation of appropriate α-alkyl homoterephthalate esters with 2,4-diamino-6-(bromomethyl)-8-deazapteridine afforded 10-alkyl-10-carboxy-4-amino-4-deox