88392-97-6

Upstream product

• 88392-93-2 dimethyl 4-amino-4-deoxy-10-carboxy-8,10-dideazapteroate 
• 76807-56-2 2,4-diamino-6-(bromomethyl)pyrido<3,2-d>pyrimidine 
• 52787-14-1 methyl 4-(2-methoxy-2-oxoethyl)benzoate 
• 187242-92-8 4-[2-(6-Cyano-5-nitro-pyridin-2-yl)-ethyl]-benzoic acid methyl ester 
• 187242-89-3 4-[2-(6-Chloro-5-nitro-pyridin-2-yl)-ethyl]-benzoic acid methyl ester 
• 187242-87-1 4-[2-(6-Amino-5-nitro-pyridin-2-yl)-ethyl]-benzoic acid methyl ester 
• 187242-94-0 4-[2-(5-Amino-6-cyano-pyridin-2-yl)-ethyl]-benzoic acid methyl ester 
• 187242-84-8 4-((E)-5-Dimethylamino-3-oxo-pent-4-enyl)-benzoic acid methyl ester 
• 1025940-85-5 4-((1E,4E)-5-Dimethylamino-3-oxo-penta-1,4-dienyl)-benzoic acid methyl ester 
• 187242-82-6 (E)-4-(3-oxobut-1-en-1-yl)benzoic acid 
• 187242-95-1 4-[2-(2,4-Diamino-pyrido[3,2-d]pyrimidin-6-yl)-ethyl]-benzoic acid butyl ester 

Downstream Products

• 85325-88-8 (S)-2-{4-[2-(2,4-Diamino-pyrido[3,2-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid diethyl ester 
• 129119-87-5 8,10-dideazafolic acid diethyl ester 
• 129119-89-7 8,10-dideazafolic acid 

Relevant academic research and scientific papers

Versatile synthesis of 6-substituted 8-deazapteridine-2,4-diamines. Formal total synthesis of 8,10-dideazaminopterin

A new synthesis of 4-amino-4-deoxy-8,10-dideazapteroic acid (11d) and 6-substituted and 5,6-anellated 8-deazapteridine-2,4-diamines, 10a, 10d, 25, is described. Starting from keteneaminals 1 or 12 and enaminones 4 or β-aminoketone 17 the title compounds can be prepared via functional group transformation of 2-amino-3-nitropyridines 5 or nicotinate 13a yielding 3-amino-α-picolinonitriles 9 which are cyclocondensed with guanidine.

Synthesis and antifolate properties of 10-alkyl-8,10-dideazaminopterins

The synthesis of 10-alkyl analogues of the potent antitumor agent 8,10-dideazaminopterin is described. Alkylation of appropriate α-alkyl homoterephthalate esters with 2,4-diamino-6-(bromomethyl)-8-deazapteridine afforded 10-alkyl-10-carboxy-4-amino-4-deox