883972-56-3Relevant academic research and scientific papers
Lewis Acid Mediated Electrophilic Cyanation of 2,2′-Biphenols
Zhang, Wu,Yang, Wen,Zhao, Wanxiang
, p. 8702 - 8713 (2020)
A Lewis acid mediated electrophilic cyanation of 2,2′-biphenols with a trifluoromethanesulfonyl (Tf) protecting group is reported. The cyanation reactions with less toxic, commercially available MeSCN as a cyanating reagent afforded a range of 3-cyan-2,2′-biphenols in moderate to high yields. The use of trifluoromethanesulfonyl (Tf) as a protecting group is crucial to the success of this transformation. Moreover, the cyanated products were readily transformed into various synthetically useful molecules. This protocol features high efficiency, excellent regioselectivity, and good functional group compatibility and may provide a practical tool for the synthesis and modification of biologically active compounds, catalysts, and ligands.
Regioselective Construction of Functionalized Biarylols by Fe(OTf)3-Catalyzed Direct Arylation of 1-Diazonaphthalen-2(1H)-ones and Their Fluorescence Properties
Somai Magar, Krishna Bahadur,Edison,Lee, Yong Rok
, p. 7046 - 7054 (2017/12/28)
A facile and efficient protocol for the construction of functionalized biarylols by Fe(OTf)3-catalyzed direct arylation of 1-diazonaphthalen-2(1H)-ones with arenes has been developed. This methodology provides diverse 1-arylnaphthalen-2-ols in moderate to good yields. This approach has also been applied to the synthesis of biologically interesting polycyclic-aromatic-substituted and heteroaryl-substituted naphthalen-2-ols. The synthesized compounds bearing an anthracene scaffold can be useful as potential fluorescent biomarkers for confocal imaging of clone cells.
Synthesis of unsymmetrical o-biphenols and o-binaphthols via silicon-tethered Pd-catalyzed C-H arylation
Huang, Chunhui,Gevorgyan, Vladimir
supporting information; experimental part, p. 2442 - 2445 (2010/07/10)
A mild, practical, and efficient method for the synthesis of unsymmetrical o-biphenols (including o-phenol-naphthols and o-binaphthols) has been developed. Unsymmetrical bis-aryloxy silanes, which were readily prepared in a semi-one-pot fashion, underwent the Pd-catalyzed intramolecular arylation followed by a routine TBAF desilylation step to furnish valuable unsymmetrical biphenols without necessity of isolation of seven-membered intermediates. The excellent functional group tolerance allows for synthesis of a variety of functionalized o-biphenols and o-binaphthols from easily available staring materials.
