883985-06-6 Usage
Description
(R)-1-Benzyl 5-Methyl 2-((tert-butoxycarbonyl)aMino)pentanedioate is a dipeptide derivative that serves as a crucial building block in the synthesis of pharmaceuticals and organic compounds. This white solid has a molecular formula of C18H25NO6 and a molecular weight of 351.39 g/mol. Its unique structure and reactivity make it a valuable tool in organic chemistry and drug discovery, often utilized as a chiral auxiliary in asymmetric synthesis.
Uses
Used in Pharmaceutical Synthesis:
(R)-1-Benzyl 5-Methyl 2-((tert-butoxycarbonyl)aMino)pentanedioate is used as a key component in the development of peptide-based drugs. Its role in pharmaceutical synthesis is to provide a structural foundation for the creation of various medications, contributing to the advancement of novel therapeutic options.
Used in Organic Chemistry:
In the field of organic chemistry, (R)-1-Benzyl 5-Methyl 2-((tert-butoxycarbonyl)aMino)pentanedioate is employed as a chiral auxiliary in asymmetric synthesis. Its unique properties allow for the creation of enantiomerically pure compounds, which are essential in the development of more effective and selective drugs.
Used in Drug Discovery:
(R)-1-Benzyl 5-Methyl 2-((tert-butoxycarbonyl)aMino)pentanedioate's reactivity and structural characteristics make it a valuable asset in drug discovery. Researchers can leverage its properties to design and synthesize new drug candidates with improved pharmacological profiles, potentially leading to breakthroughs in the treatment of various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 883985-06-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,3,9,8 and 5 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 883985-06:
(8*8)+(7*8)+(6*3)+(5*9)+(4*8)+(3*5)+(2*0)+(1*6)=236
236 % 10 = 6
So 883985-06-6 is a valid CAS Registry Number.
883985-06-6Relevant articles and documents
Synthesis of the (3R,6S)-3-amino-6-(2,3-difluorophenyl)azepan-2-one of telcagepant (MK-0974), a calcitonin gene-related peptide receptor antagonist for the treatment of migraine headache
Burgey, Christopher S.,Paone, Daniel V.,Shaw, Anthony W.,Deng, James Z.,Nguyen, Diem N.,Potteiger, Craig M.,Graham, Samuel L.,Vacca, Joseph P.,Williams, Theresa M.
supporting information; experimental part, p. 3235 - 3238 (2009/05/27)
(Chemical Equation Presented) Two novel routes have been developed to the (3R,6S)-3-amino-6-(2,3-difluorophenyl)-1-(2,2,2-trifluoroethyl)azepan-2-one 2 of the CGRP receptor antagonist clinical candidate telcagepant (MK-0974, 1). The first employs a ring-closing metathesis of the styrene 7 as the key reaction, while the second makes use of a highly diastereoselective Hayashi-Miyaura Rh-catalyzed arylboronic acid addition to nitroalkene 16. The latter route has been implemented to produce multigram quantities of telcagepant for extensive preclinical evaluation.
CGRP RECEPTOR ANTAGONISTS
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Page/Page column 101, (2010/11/08)
Compounds of Formula (I): and Formula (II): (where variables R2, R4, A, B, D, W, X, Y and Z are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
