883985-18-0

Basic information

• Product Name: 2-[4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl]acetic acid
• Synonyms: 2-[4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl]acetic acid
• CAS NO: 883985-18-0
• Molecular Weight: 340.335
• Mol File: 883985-18-0.mol

Chemical Properties

• CAS DataBase Reference: 2-[4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl]acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl]acetic acid(883985-18-0)
• EPA Substance Registry System: 2-[4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl]acetic acid(883985-18-0)

Safety Data

• Hazardous Substances Data: 883985-18-0(Hazardous Substances Data)

Upstream product

• 156-38-7 4-hydroxyphenylacetate 
• 13790-39-1 6,7-dimethoxy-4-chloroquinazoline 

Downstream Products

• 1355221-44-1 C₂₁H₁₉N₅O₄ 
• 883986-23-0 C₂₃H₂₃N₅O₄ 
• 883988-38-3 2-[4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl]acetyl chloride 

Relevant articles and documents

Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases

A new series of Quinazoline Ether Inhibitor which potently inhibits VEGFR-2 and PDGFR tyrosine kinases is described here. In vitro, pharmacokinetics and in vivo evaluations led to the selection of AZD2932.

QUINAZOLINE DERIVATIVES

The invention concerns quinazoline derivatives of Formula (I) or a pharmaceutically-acceptable salt, solvate or pro-drug thereof, wherein each of X1, p, R1, q, R2, R3, R4, R5, Ring A, r and R6 has any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of cell proliferative disorders or in the treatment of disease states associated with angiogenesis and/or vascular permeability.