883992-08-3

Upstream product

• 78436-46-1 1-{3-[1-(p-chlorobenzoyl-5-methoxy-2-methyl)-indolacetyl]}-imidazole 
• 133699-09-9 10,10,10-triphenyl-3,6,9-trioxadecan-1-ol 
• 76-83-5 trityl chloride 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 
• 53-86-1 [1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid 

Downstream Products

• 157769-09-0 [1-(4-Chloro-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-acetic acid 2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethyl ester 

Relevant academic research and scientific papers

Synthesis and stability of two indomethacin prodrugs

The purpose of this study was to synthesize and study the in vitro enzymatic and non-enzymatic hydrolysis of indomethacin-TEG ester and amide prodrugs. It was found that the ester conjugate 10 was comparatively stable between pH 3 and 6 (half-life >90 h),