88406-73-9Relevant academic research and scientific papers
Reaction of Ethyl 4-Bromoacetoacetate with Carbon Disulfide and Active Methylene Compounds
Chiba, Takuo,Sato, Hirotoshi,Kato, Tetsuzo
, p. 2480 - 2483 (2007/10/02)
Reaction of ethyl 4-bromoacetoacetate (1) with 2-cyanoethene-1,1-dithiol derivatives (prepared from carbon disulfide and active methylene compounds such as ethyl cyanoacetate and malononitrile in the presence of sodium hydride) gave 2-substituted 4-hydroxy-1,3-dithiolane-4-acetates, 2a and 2b.On the other hand, reaction of 1 with 2-cyano-1-methylthioethene-1-thiol derivatives (prepared from 2-cyanoethene-1,1-dithiol derivatives and methyl iodide) gave 4-substituted 3-amino-5-methylthiothiophene-2-(3-oxo)propionates, 5a and 5b.Keywords - ethyl 4-bromoacetoacetate; carbon disulfide; ethyl cyanoacetate; malononitrile; 1,3-dithiolane-4-acetate; 1,3-dithiole-4-acetate; 2-thiophenepropionate
