88408-80-4Relevant academic research and scientific papers
Fenton-Inspired C-H Functionalization: Peroxide-Directed C-H Thioetherification
Groendyke, Brian J.,Modak, Atanu,Cook, Silas P.
, p. 13073 - 13091 (2019/10/10)
Substoichiometric iron mediates the thioetherification of unactivated aliphatic C-H bonds directed by resident silylperoxides. Upon exposure to a catalytic amount of iron(II) triflate, TIPS-protected peroxides bearing primary, secondary, and tertiary C-H sites undergo chemoselective thioetherification of remote C-H bonds with diaryl disulfides. The reaction demonstrates a broad substrate scope and functional group tolerance without the use of any noble metal additives. Mechanistic experiments suggest that the reaction proceeds through 1,5-H atom abstraction by a hydroxyl radical generated with iron.
Stereoselective synthesis of the macrolactone core of (+)-neopeltolide
Raghavan, Sadagopan,Samanta, Pradip Kumar
, p. 2346 - 2349 (2012/07/01)
A stereoselective synthesis of the macrolactone core of the potent anticancer agent neopeltolide is disclosed. The key steps of the synthesis include asymmetric allylation using Krische' protocol, conjugate reduction using MacMillan's methodology, and an
PREPARATION OF CHIRAL C5-BUILDING BLOCKS FOR TERPENE SYNTHESIS BY BAKERS' YEAST REDUCTION OF SULFUR-FUNCTIONALIZED PRENYL DERIVATIVES
Sato, Toshio,Hanayama, Kyoko,Fujisawa, Tamotsu
, p. 2197 - 2200 (2007/10/02)
Enantioselective hydrogenation of several α,β-unsaturated aldehydes and allylic alcohols of sulfur-functionalized prenyl derivatives with bakers' yeast gave bifunctional chiral (S)- and (R)-C5-building blocks for terpene synthesis with high enantiomeric e
Certain polyprenyl intermediates
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, (2008/06/13)
Novel polyprenyl compounds have the general formula: STR1 represents a cis-isoprene unit, n is an integer of 11-19, Z1 is --CH2 OH or a functional precursor thereof, and either one of R1 and R2 is a hydrogen ato
