88413-05-2Relevant academic research and scientific papers
AROMATIC AMIDES AS INHIBITORS OF C-FMS KINASE
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Page/Page column 75, (2008/06/13)
The invention relates to compounds of Formula (I), wherein A, X, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, colon cancer, stomach cancer, hairy cell leukemia and non-small lung carcinoma; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including arthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula (I), are also provided.
Potential Antitumor Agents. 41. Analogues of Amsacrine with Electron-Donor Substituents in the Anilino Ring
Atwell, Graham J.,Rewcastle, Gordon W.,Denny, William A.,Cain, Bruce F.,Baguley, Bruce C.
, p. 367 - 372 (2007/10/02)
The preparation and antitumor activity of a series of 3'-alkylamino and 3'-dialkylamino analogues of amsacrine are reported.The results support previous work suggesting that the presence of electron-donating groups in the 3'-position of the anilino ring s
