88418-34-2Relevant academic research and scientific papers
Directing-Group-Based Strategy Enabling Intermolecular Heck-Type Reaction of Cycloketone Oxime Esters and Unactivated Alkenes
Cheng, Gui-Juan,Deng, Yi,Fu, Junkai,Li, Xuexiang,Wang, Hongwei,Zhao, Chunyang,Zhou, Yu
supporting information, p. 3524 - 3530 (2020/04/30)
A new type of coupling between unactivated olefins and nonstabilized alkyl radicals was achieved, which enabled the first intermolecular Heck-type reaction of cycloketone oxime esters and unactivated alkenes. This directing-group-based strategy was compatible with various unactivated alkenes and cyclobutanone-, cyclopentanone-, and cyclohexanone-derived oxime esters. Density functional theory calculations showed that both excellent regioselectivities and good diastereoselectivities could be ascribed to the 2-butanol-assisted concerted H-OBz elimination of the conformationally strained metallacyclic transition state.
Practical Direct α-Arylation of Cyclopentanones by Palladium/Enamine Cooperative Catalysis
Xu, Yan,Su, Tianshun,Huang, Zhongxing,Dong, Guangbin
supporting information, p. 2559 - 2563 (2016/02/18)
Direct arylation of cyclopentanones has been a long-standing challenge because of competitive self-aldol condensation and multiple arylations. Reported herein is a direct mono-α-C-H arylation of cyclopentanones with aryl bromides which is enabled by palla
Substituted hexahydropyrrolo[1,2-a]-quinolines, hexahydro-1H-pyrido[1,2-a]-q
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, (2008/06/13)
Tricyclic benzo fused compounds of the formula STR1 and pharmaceutically acceptable cationic and acid addition salts thereof, wherein n is zero, 1 or 2, and t is 1 or 2; M is CH or N, R1 is H or certain acyl groups; Q is CO2 R4, COR5, C(OR7)R5 R6, CN, CONR9 R10, CH2 NR9 R10, CH2 NHCOR11, CH2 NHSO2 R12, 5-tetrazolyl or when n is 1, Q and OR1 together form a lactone or certain reduced derivatives thereof; and Z is certain alkyl, alkoxy, alkoxyalkyl, aralkyl, aralkoxy, aryloxyalkyl or aralkoxyalkyl groups, are valuable central nervous system active agents, methods for their use, pharmaceutical compositions containing them and certain intermediates therefor.
PHOTOLYSIS OF CIS- AND TRANS-2-(3,5-DIMETHOXYPHENYL)CYCLOPENTYL METHANESULFONATE. STEREOELECTRONIC REQUIREMENT FOR PHOTOSOLVOLYSIS
Jaeger, David A.,Bernhardt, Emily A.
, p. 4521 - 4524 (2007/10/02)
On irradiation in methanol, trans-2-(3,5-dimethoxyphenyl)cyclopentyl methanesulfonate underwent photosolvolysis whereas the cis-isomer did not; thus, for photosolvolysis there exists a trans-requirement of excited aryl group and leaving group.
