88418-69-3

Usage

Uses

Used in Biochemistry Research:
4-ISOCYANATO-TEMPO is used as a labeling agent for RNA, enabling researchers to track and analyze the structure, dynamics, and interactions of RNA molecules using EPR spectroscopy. This technique provides valuable insights into the function and behavior of RNA in various biological processes.
Used in Analytical Chemistry:
In the field of analytical chemistry, 4-ISOCYANATO-TEMPO is employed as a derivatizing agent for the detection and quantification of various analytes. Its ability to form stable covalent bonds with target molecules allows for the sensitive and selective analysis of compounds in complex samples.
Used in Material Science:
4-ISOCYANATO-TEMPO is also utilized in material science for the development of advanced materials with unique properties. Its incorporation into polymers and other materials can result in improved stability, self-healing capabilities, and enhanced performance in various applications.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 4-ISOCYANATO-TEMPO is employed as a tool for the design and synthesis of new drug candidates. Its ability to form stable radicals can be harnessed to develop novel therapeutic agents with improved pharmacokinetic and pharmacodynamic properties.
Overall, 4-ISOCYANATO-TEMPO is a versatile compound with a wide range of applications across various scientific disciplines, making it an important asset in the advancement of research and development efforts.

InChI:InChI=1/C10H17N2O2/c1-9(2)5-8(11-7-13)6-10(3,4)12(9)14/h8H,5-6H2,1-4H3/q-1

Upstream product

• 124-38-9 carbon dioxide 
• 88418-68-2 4-(diethylphosphorylamino)-2,2,6,6-tetramethylpiperidine-1-oxyl 
• 37654-42-5 4-isocyano-2,2,6,6-tetramethylpiperidine-1-oxyl 
• 14691-88-4 4-amino-2,2,6,6-tetramethyl-1-piperidine-1-oxyl 
• 503-38-8 trichloromethyl chloroformate 

Downstream Products

• 934543-30-3 N-(2,2,6,6-tetramethylpiperidin-1-oxyl-4-yl)morpholine-4-carboxamide 
• 126479-63-8 1-(2,2,6,6-tetramethylpiperidin-1-oxyl-4-yl)-3-(2-deoxy-1,3,4,6-tetra-O-acetyl-D-glucos-2-yl)-1-nitrosourea 
• 1448017-24-0 C₁₉H₂₈N₃O₄ 
• 127213-35-8 4-<(2,4-dioxo-5-fluoro-1,2,3,4-tetrahydro-1-pyrimidinyl)carbonylamino>-2,2,6,6-tetramethyl-1-piperidinyloxyl 

Relevant academic research and scientific papers

4-Isocyano-2,2,6,6-tetramethylpiperidin-1-oxyl: A valuable precursor for the synthesis of new nitroxides

To enrich the limited set of isonitriles typically employed, 4-isocyano-2,2,6,6-teramethylpiperidin-1-oxyl (1) is proposed as an isonitrile bearing a nitroxyl moiety, Isocyanide 1 was used in some reactions characteristic of isonitriles. Isoselenocyanate, amides (products of Passerini and Ugi reactions), and tetrazole derivative were obtained. The EPR spectra of the urea derivative 5b and a product of an Ugi reaction 7 (both dinitroxides) were analyzed.

Reactions of nitroxides with sulfur-containing compounds, part IV: Synthesis of novel nitroxide (thio)ureas

The reactions of 4-isothiocyanato-2,2, 6,6-tetramethylpiperidine-1-oxyl 2 and 4-isocyanato-2,2,6,6-tetramethylpiperidine-1-oxyl 3 with selected amines and lower alcohols give the corresponding novel thioureas 4, ureas 5, thiocarbamates 6, and carbamates 7, all bearing the nitroxyl moiety. The characteristic features of EI mass spectra of (thio)ureas 4 and 5 are described. Some of the synthesized thioureas 4, ureas 5, thiocarbamates 6, and carbamates 7 are moderately or weakly active against pathogenic fungi.

Synthesis and Characterization of a New Diacetylene with Terminal Nitroxyl Radical Groups

The new diacetylene 4 was prepared from 4-isocyanato-2,2,6,6-tetramethylpiperidin-1-oxyl (2) and 2,4-hexadiyne-1,6-diol (3).The diacetylene 4 could not be polymerized by irradiation or thermal treatment, but decomposition and loss of paramagnetic properties was observed.A new synthesis of isocyanate 2 is also described. Key Words: Nitroxyl radicals / Diacetylenes / Topochemical polymerisation