88418-69-3

Basic information

• Product Name: 4-ISOCYANATO-TEMPO
• Synonyms: 4-ISOCYANATO-TEMPO;4-Isocyanato-2,2,6,6-tetramethyl-1-piperidinyloxy;4-Isocyanato-TEMPO, Technical grade (approximately 85%)
• CAS NO: 88418-69-3
• Molecular Formula: C₁₀H₁₇N₂O₂
• Molecular Weight: 197.25418
• Product Categories: Spin Labeling Compounds;Heterocycles
• Mol File: 88418-69-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 102°C
• Boiling Point: 271.5°C at 760 mmHg
• Flash Point: 118°C
• Appearance: /
• Vapor Pressure: 0.0018mmHg at 25°C
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• Stability: Moisture sensitive
• CAS DataBase Reference: 4-ISOCYANATO-TEMPO(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ISOCYANATO-TEMPO(88418-69-3)
• EPA Substance Registry System: 4-ISOCYANATO-TEMPO(88418-69-3)

Safety Data

• Hazardous Substances Data: 88418-69-3(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 88418-69-3 differently. You can refer to the following data:
1. 4-isocyanato TEMPO is used to label RNA and analyze by EPR
2. Used to label RNA and analyze by EPR.

InChI:InChI=1/C10H17N2O2/c1-9(2)5-8(11-7-13)6-10(3,4)12(9)14/h8H,5-6H2,1-4H3/q-1

Upstream product

• 37654-42-5 4-isocyano-2,2,6,6-tetramethylpiperidine-1-oxyl 
• 14691-88-4 4-amino-2,2,6,6-tetramethyl-1-piperidine-1-oxyl 
• 503-38-8 trichloromethyl chloroformate 
• 124-38-9 carbon dioxide 
• 88418-68-2 4-(diethylphosphorylamino)-2,2,6,6-tetramethylpiperidine-1-oxyl 

Downstream Products

• 127213-35-8 4-<(2,4-dioxo-5-fluoro-1,2,3,4-tetrahydro-1-pyrimidinyl)carbonylamino>-2,2,6,6-tetramethyl-1-piperidinyloxyl 
• 934543-30-3 N-(2,2,6,6-tetramethylpiperidin-1-oxyl-4-yl)morpholine-4-carboxamide 
• 126479-63-8 1-(2,2,6,6-tetramethylpiperidin-1-oxyl-4-yl)-3-(2-deoxy-1,3,4,6-tetra-O-acetyl-D-glucos-2-yl)-1-nitrosourea 
• 1448017-24-0 C₁₉H₂₈N₃O₄ 

Relevant articles and documents

4-Isocyano-2,2,6,6-tetramethylpiperidin-1-oxyl: A valuable precursor for the synthesis of new nitroxides

To enrich the limited set of isonitriles typically employed, 4-isocyano-2,2,6,6-teramethylpiperidin-1-oxyl (1) is proposed as an isonitrile bearing a nitroxyl moiety, Isocyanide 1 was used in some reactions characteristic of isonitriles. Isoselenocyanate, amides (products of Passerini and Ugi reactions), and tetrazole derivative were obtained. The EPR spectra of the urea derivative 5b and a product of an Ugi reaction 7 (both dinitroxides) were analyzed.

Reactions of nitroxides with sulfur-containing compounds, part IV: Synthesis of novel nitroxide (thio)ureas

The reactions of 4-isothiocyanato-2,2, 6,6-tetramethylpiperidine-1-oxyl 2 and 4-isocyanato-2,2,6,6-tetramethylpiperidine-1-oxyl 3 with selected amines and lower alcohols give the corresponding novel thioureas 4, ureas 5, thiocarbamates 6, and carbamates 7, all bearing the nitroxyl moiety. The characteristic features of EI mass spectra of (thio)ureas 4 and 5 are described. Some of the synthesized thioureas 4, ureas 5, thiocarbamates 6, and carbamates 7 are moderately or weakly active against pathogenic fungi.

SYNTHESIS OF ISOCYANATO- AND CARBODIIMIDOPIPERIDINOXYLS FRON 4-AMINO-2,2,6,6-TETRAMETHYLPIPERIDINE-1-OXYL

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