884325-56-8

Basic information

• Product Name: 3-methyl-but-2-enoic acid (4-fluoro-2-{2-[4-(1-oxo-1H-1λ⁴-benzo[d]isothiazol-3-yl)-piperazin-1-yl]-ethyl}-phenyl)-amide
• Synonyms: 3-methyl-but-2-enoic acid (4-fluoro-2-{2-[4-(1-oxo-1H-1λ⁴-benzo[d]isothiazol-3-yl)-piperazin-1-yl]-ethyl}-phenyl)-amide
• CAS NO: 884325-56-8
• Molecular Weight: 454.568
• Mol File: 884325-56-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-methyl-but-2-enoic acid (4-fluoro-2-{2-[4-(1-oxo-1H-1λ⁴-benzo[d]isothiazol-3-yl)-piperazin-1-yl]-ethyl}-phenyl)-amide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-but-2-enoic acid (4-fluoro-2-{2-[4-(1-oxo-1H-1λ⁴-benzo[d]isothiazol-3-yl)-piperazin-1-yl]-ethyl}-phenyl)-amide(884325-56-8)
• EPA Substance Registry System: 3-methyl-but-2-enoic acid (4-fluoro-2-{2-[4-(1-oxo-1H-1λ⁴-benzo[d]isothiazol-3-yl)-piperazin-1-yl]-ethyl}-phenyl)-amide(884325-56-8)

Safety Data

• Hazardous Substances Data: 884325-56-8(Hazardous Substances Data)

Upstream product

• 331-25-9 (3-fluorophenyl)acetic acid 
• 29640-98-0 (5-Fluoro-2-nitro-phenyl)-acetic Acid 
• 865787-02-6 2-(5-fluoro-2-nitro-phenyl)-1-[4-(1-oxo-1H-1λ⁴-benzo[d]isothiazol-3-yl)-piperazin-1-yl]-ethanone 
• 865787-08-2 3-{4-[2-(5-fluoro-2-nitro-phenyl)-ethyl]-piperazin-1-yl}-benzo[d]isothiazole 1-oxide 
• 865787-14-0 4-fluoro-2-{2-[4-(1-oxo-1H-1λ⁴-benzo[d]isothiazol-3-yl)-piperazin-1-yl]-ethyl}-phenylamine 
• 3350-78-5 3,3-Dimethylacryloyl chloride 

Relevant articles and documents

8-Substituted 3,4-dihydroquinolinones as a novel scaffold for atypical antipsychotic activity

Several new, potent dopamine subtype 2 (DA D2) active compounds with serotonin subtype 2A (5-HT2A) pharmacology are presented. 8-Substituted 3,4-dihydroquinolinones, tetrahydroquinolines, and N-acyl tetrahydroquinolines were evaluated in primary assays. Subtle changes on this novel scaffold translated to large changes in potency and selectivity in vitro. These compounds show promise as novel atypical antipsychotics for the treatment of schizophrenia.