29640-98-0

Basic information

• Product Name: (5-FLUORO-2-NITRO-PHENYL)-ACETIC ACID
• Synonyms: (5-FLUORO-2-NITRO-PHENYL)-ACETIC ACID;2-NITRO-5-FLUORO PHENYLACETIC ACID;Benzeneacetic acid, 5-fluoro-2-nitro-;2-(5-fluoro-2-nitrophenyl)acetic acid
• CAS NO: 29640-98-0
• Molecular Formula: C₈H₆FNO₄
• Molecular Weight: 199.14
• Product Categories: Aromatic Phenylacetic Acids and Derivatives
• Mol File: 29640-98-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 154-156°C
• Boiling Point: 343.6°Cat760mmHg
• Flash Point: 161.6°C
• Appearance: /
• Density: 1.498g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.575
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.74±0.10(Predicted)
• CAS DataBase Reference: (5-FLUORO-2-NITRO-PHENYL)-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (5-FLUORO-2-NITRO-PHENYL)-ACETIC ACID(29640-98-0)
• EPA Substance Registry System: (5-FLUORO-2-NITRO-PHENYL)-ACETIC ACID(29640-98-0)

Safety Data

• Hazardous Substances Data: 29640-98-0(Hazardous Substances Data)

Usage

Chemical Properties

white to yellow crystal powder.

Uses

5-Fluoro-2-nitrophenylacetic acid is a useful research chemical.

Preparation

synthesis of 5-Fluoro-2-nitrophenylacetic acid: To a mixture of 23.2g of 3-fluorophenylacetic acid and 100ml. of conc. sulfuric acid is added dropwise 6.5ml. of conc. nitric acid while maintaining the tempera ture below 40°C. The mixture is stirred at ambient temperature for 24 hours and then poured onto one kilogram of ice. The resulting precipitate is recovered by filtering, washed with water and dried in vacuo to obtain crude 5-fluoro-2-nitrophenylacetic acid, m.p. 137-142°C.

InChI:InChI=1/C8H6FNO4/c9-6-1-2-7(10(13)14)5(3-6)4-8(11)12/h1-3H,4H2,(H,11,12)

Upstream product

• 29640-99-1 methyl 2-(5-fluoro-2-nitrophenyl)acetate 
• 1875-89-4 2-(3-methylphenyl)ethanol 
• 64123-77-9 methyl (3-fluorophenyl)acetate 
• 331-25-9 (3-fluorophenyl)acetic acid 

Downstream Products

• 168292-21-5 (S)-{(R)-2-[2-(5-Fluoro-2-nitro-phenyl)-acetylamino]-3-phenyl-propionylamino}-(3-isopropoxy-5-methoxy-phenyl)-acetic acid methyl ester 
• 865787-02-6 2-(5-fluoro-2-nitro-phenyl)-1-[4-(1-oxo-1H-1λ⁴-benzo[d]isothiazol-3-yl)-piperazin-1-yl]-ethanone 
• 865787-05-9 1-(4-benzo[d]isoxazol-3-yl-piperazin-1-yl)-2-(5-fluoro-2-nitro-phenyl)-ethanone 
• 677708-77-9 1-(4-1,2-benzisothiazol-3-yl-piperazin-1-yl)-2-(5-fluoro-2-nitro-phenyl)-ethanone 
• 29640-99-1 methyl 2-(5-fluoro-2-nitrophenyl)acetate 
• 56341-41-4 5-fluoroindol-2(3H)-one 
• 168292-12-4 (8S,11R)-11-Benzyl-5-methoxy-16-nitro-10,13-dioxo-2-oxa-9,12-diaza-tricyclo[13.3.1.1^3,7]icosa-1⁽¹⁸⁾,3,5,7⁽²⁰⁾,15⁽¹⁹⁾,16-hexaene-8-carboxylic acid methyl ester 
• 168292-22-6 (S)-{(R)-2-[2-(5-Fluoro-2-nitro-phenyl)-acetylamino]-3-phenyl-propionylamino}-(3-hydroxy-5-methoxy-phenyl)-acetic acid methyl ester 
• 884325-56-8 3-methyl-but-2-enoic acid (4-fluoro-2-{2-[4-(1-oxo-1H-1λ⁴-benzo[d]isothiazol-3-yl)-piperazin-1-yl]-ethyl}-phenyl)-amide 
• 677708-91-7 3-methyl-but-2-enoic acid {2-[2-(4-benzo[d]isoxazol-3-yl-piperazin-1-yl)-ethyl]-4-fluoro-phenyl}-amide 
• 677708-80-4 3-methyl-but-2-enoic acid {2-[2-(4-1,2-benzisothiazol-3-yl-piperazin-1-yl)-ethyl]-4-fluoro-phenyl}-amide 
• 865787-08-2 3-{4-[2-(5-fluoro-2-nitro-phenyl)-ethyl]-piperazin-1-yl}-benzo[d]isothiazole 1-oxide 

Relevant articles and documents

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Sleep inducers of the formula: STR1 wherein R is hydrogen or halo of atomic weight of from 18 to 36, R' is hydrogen, halo or CF3 and R° is hydrogen or lower alkyl. Preparation by cyclizing a 2-nitro-phenylacetic acid is also disclosed.