884340-91-4

Usage

Uses

Used in Pharmaceutical Industry:
4-CHLORO-5,7-DIMETHOXYQUINAZOLINE is used as a building block for the synthesis of various pharmaceuticals due to its unique structure and reactivity, which allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, 4-CHLORO-5,7-DIMETHOXYQUINAZOLINE is utilized as a component in the creation of agrochemicals, contributing to the development of effective products for agricultural use.
Used in Antituberculosis Applications:
4-CHLORO-5,7-DIMETHOXYQUINAZOLINE has been studied for its potential as an antituberculosis agent, indicating its use in the development of treatments for tuberculosis.
Used in Antifungal Applications:
4-CHLORO-5,7-DIMETHOXYQUINAZOLINE has also shown promise as an antifungal agent, making it a candidate for use in the development of antifungal medications to combat fungal infections.

Upstream product

• 379228-27-0 5,7-dimethoxyquinazolin-4(3H)-one 
• 21577-57-1 2-amino-4,6-dimethoxybenzoic acid 
• 379228-26-9 methyl 2-amino-4,6-dimethoxybenzoate 

Downstream Products

• 692726-14-0 (2-chloro-5-methoxy-phenyl)-(5,7-dimethoxy-quinazolin-4-yl)-amine 
• 1355221-16-7 C₂₂H₂₁N₅O₅ 
• 1301760-69-9 3-{[5,7-bis(methyloxy)-4-quinazolinyl]amino}-4-(dimethylamino)-N-methylbenzenesulfonamide 
• 379228-25-8 4-[(2-chloro-5-methoxyphenyl)amino]-7-methoxyquinazolin-5-ol 

Relevant academic research and scientific papers

CHEMICAL COMPOUNDS

The invention relates to chemical compounds of the formula (I) or pharmaceutically acceptable salts thereof, which possess B Raf inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.

PYRAZOLYLAMINO SUBSTITUTED QUINAZOLES FOR THE TREATMENT OF CANCER

The invention provided a compound of formula: (I) for use in the treatment of disease, in particular proliferative diseases such as cancer and for use in the preparation of medicaments for use in the treatment of proliferative diseases; the invention also

N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy] -5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor

Src family kinases (SFKs) are nonreceptor tyrosine kinases that are reported to be critical for cancer progression. We report here a novel subseries of C-5-substituted anilinoquinazolines that display high affinity and specificity for the tyrosine kinase domain of the c-Src and Abl enzymes. These compounds exhibit high selectivity for SFKs over a panel of recombinant protein kinases, excellent pharmacokinetics, and in vivo activity following oral dosing. N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine (AZD0530) inhibits c-Src and Abl enzymes at low nanomolar concentrations and is highly selective over a range of kinases. AZD0530 displays excellent pharmacokinetic parameters in animal preclinically and in man (t1/2 = 40 h). AZD0530 is a potent inhibitor of tumor growth in a c-Src-transfected 3T3-fibroblast xenograft model in vivo and led to a significant increase in survival in a highly aggressive, orthotopic model of human pancreatic cancer when dosed orally once daily. AZD0530 is currently undergoing clinical evaluation in man.

QUINAZOLINE DERIVATIVES FOR USE AGAINST CANCER

The invention concerns quinazoline derivatives of Formula (I) or a pharmaceutically-acceptable salt, solvate or pro-drug thereof, wherein each of p, R1, q, R2, R3, R4, R5, Ring A, X1, R6, r and R7 has any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of cell proliferative disorders or in the treatment of disease states associated with angiogenesis and/or vascular permeability.

CHEMICAL COMPOUNDS

Quinazoline derivatives of formula (I); for use in the treatment of proliferative diseases such as cancer and in the preparation of medicaments for use in the treatment of proliferative diseases, and to processes for their preparation, as well as pharmaceutical compositions containing them as active ingredient.