88445-02-7

Upstream product

• 1066-26-8 sodium acetylide 
• 611-70-1 phenyl isopropyl ketone 
• 74-86-2 acetylene 
• 70277-75-7 lithium acetylide 
• 75-20-7 calcium carbide 
• 4301-14-8 acetylenemagnesium bromide 

Downstream Products

• 72420-37-2 3-hydroxy-4-methyl-3-phenyl-2-pentanone 
• 65050-80-8 4-methyl-3-phenylpent-3-en-1-yne 
• 106113-12-6 2-methyl-3,6-diphenyloct-4-yn-3,6-diol 
• 136722-07-1 3-hydroxy-2-methyl-3-phenyl-9-dimethylaminonon-7-yn-4-one 
• 1366542-82-6 allyl (4-methyl-3-phenylpent-1-yn-3-yl) carbonate 
• 1446099-84-8 (E)-1-(dimethyl(phenyl)silyl)-4-methyl-3-phenylpent-1-en-3-ol 
• 106359-45-9 (Z)-4-methyl-3-phenylpent-2-enenitrile 
• 106359-46-0 (2E)-4-methyl-3-phenylpent-2-enenitrile 

Relevant academic research and scientific papers

Direct Exploitation of the Ethynyl Moiety in Calcium Carbide Through Sealed Ball Milling

Ball milling of calcium carbide (CaC2) enables the reaction of its ethynyl moiety with organic electrophiles. This was realized simply by co-milling CaC2 with organic substrates in a sealed jar without the need for an additive or a catalyst. Various ketones including those bearing α-hydrogens were ethynylated in good yields at short reaction times. Aryl halides are also amenable substrates for this protocol as they furnish aryl ethynes through a benzyne intermediate. This method offers a practical and cheap alternative to the established procedures for introducing ethynyl functionalities.

Transition-Metal-Free Radical Hydrotrifluoromethylation of Alkynes

A combination of readily available and bench-stable CF3SO2Na and tBuOOH was efficiently used for hydrotrifluoromethylation of alkynes. An excellent trans-selectivity was demonstrated in the synthesis of alkenes. The developed mild reaction conditions allow the supression of the competing Meyer–Schuster-type rearrangement.

GROUP 8 TRANSITION METAL CATALYSTS AND METHOD FOR MAKING SAME AND PROCESS FOR USE OF SAME IN METATHESIS REACTION

Metal catalyst compounds are disclosed. The catalyst compound are represented by the formula (I-II and VII): wherein M is a Group 8 metal; X is an anionic ligand; L is a neutral two electron donor ligand; K 22(A-E) is a ditopic or multitopic ligand. Also disclosed is an easy applicable catalyst synthesis and the application in different olefin metathesis processes, e.g. Reaction Injection Molding (RIM), rotational molding, vacuum infusion, vacuum forming, process for conversion of fatty acids and fatty acid esters or mixtures thereof, in –olefins, dicarboxylic acids or dicarboxylic esters, etc.

Alkyl group-tagged ruthenium indenylidene complexes: Synthesis, characterization and metathesis activity

We report on the synthesis of ruthenium indenylidene catalysts [RuCl2(3-R-1-indenylidene)(PCy3)2 in which R is iso-propyl (7a), tert-butyl (7b) or cyclohexyl (7c)]. The obtained alkyl tagged indenylidene catalysts were ana

CATALYST COMPLEXES WITH CARBENE LIGAND AND METHOD FOR MAKING SAME AND USE IN METATHESIS REACTION

This invention relates to catalyst compounds and the synthesis and applications useful in olefin metathesis reactions. The catalyst compounds of the invention are represented by the formula (I): wherein M is a Group 8 metal; X1 and X2/sup

Bronsted acid mediated nitrogenation of propargylic alcohols: An efficient approach to alkenyl nitriles

A novel and efficient approach to alkenyl nitriles from readily available propargylic alcohols has been developed. This nitrogenation reaction is transition-metal-free and could be conducted under air at ambient temperature, which makes this protocol promising and practical. Moreover, NH4Br is disclosed as an efficient additive to promote the stereoselectivity of this reaction. the Partner Organisations 2014.

Regioselective Rh2(OAc)4-Promoted Reactions of Methyl Diazoacetate with Terminal Triple Bond Enynes

The selective Rh2(OAc)4-promoted methoxycarbonylmethylenation of a triple bond in enynes, with a terminal triple bond, by methyl diazoacetate is established, and the main factors, affecting the regioselectivity of the process, are elucidated.The easy in s

Analogues of oxybutynin. Synthesis and antimuscarinic and bladder activity of some substituted 7-amino-1-hydroxy-5-heptyn-2-ones and related compounds

Oxybutynin chloride [4-(diethylamino)-2-butynyl α-cyclohexyl-α-hydroxybenzeneacetate hydrochloride, Ditropan] is widely used for the relief of symptoms in neurogenic bladder. This is a result of its combined anticholinergic, antispasmodic, and local anesthetic activities. In a study directed toward development of agents possessing the beneficial properties of oxybutynin, but having a longer duration of action, a series of metabolically more stable keto analogues of the parent ester, i.e. substituted 7-amino-1-hydroxy-5-heptyn-2-ones along with some analogues and derivatives, was prepared and evaluated for in vitro and in vivo antimuscarinic action in guinea pig preparations. Several members of the series were potent antimuscarinics having a longer duration of activity than that of oxybutynin in a guinea pig cystometrogram model. On the basis of its in vitro and in vivo antimuscarinic activity, coupled with a 5-fold greater duration of action than that of oxybutynin, 1-cyclobutyl-7-(dimethylamino)-1-hydroxy-1-phenyl-5-heptyn-2-one (14b) was selected for clinical evaluation.

The Effect of the Structure of Substartes and Reaction Conditions on the Preparation of Acetylene 1,4-diols. II. Two-stage Syntheses

Twelve reactions of the preparation of asymmetric acetylene 1,4-diols have been carried out (Scheme I).A significant effect of the structure of initial ketone and the reaction conditions on the preparation of diols has been found in the first stage of the synthesis (prepartion of acetylene carbinol).For R1 or R2 = p-CH3OC6H4 products of dehydration of the dils have been obtained.

Optically active propargyl alcohol derivative and a method for preparation of the same

An optically active propargyl alcohol derivative of the formula (I) STR1 wherein X=phenyl or thienyl and R=lower alkyl, halogenated methyl, phenyl or substituted phenyl having at least one lower alkyl radical and or halogen atom, is prepared by contacting a racemic modification of l- and d-isomers of the formula (I) with l-brucine in an organic solvent, by separating the resultant deposited diastereomer from a solution containing the resultant other diastereomer in the organic solvent, by decomposing each diastereomer with an aqueous mineral acid solution in the presence of an organic solvent capable of dissolving the corresponding optically active isomer dissociated from the diastereomer and incompatible with water so as to allow the optically active isomer to be dissolved in the water-incompatible organic solvent, and by recovering the optically active isomer from the solution thereof.