884489-17-2

Upstream product

• 66223-53-8 trans-2-bromocinnamaldehyde 
• 1313733-83-3 C₂₂H₂₉BrNO₅P 
• 1313733-72-0 C₂₀H₂₇BrNO₄P 
• 1313733-77-5 diethyl 1-(2-bromophenyl)-3-oxopropylphosphonate 
• 942631-67-6 (E)-diethyl 3-(benzyloxy)imino-1-phenylpropylphosphonate 
• 7749-92-0 diethyl 2-formyl-1-phenylethylphosphonate 
• 33973-22-7 (1-Phenyl-3-butenyl)phosphonsaeure-diethylester 
• 1080-32-6 O,O-diethyl benzylphosphonate 
• 884489-13-8 diethyl 3-(benzyloxy)imino-1-phenylpropylphosphonate 
• 884489-14-9 (3-benzyloxyamino-1-phenyl-propyl)-phosphonic acid diethyl ester 
• 852326-96-6 [3-(acetyl-benzyloxy-amino)-1-phenyl-propyl]-phosphonic acid diethyl ester 

Relevant academic research and scientific papers

Design, synthesis, and X-ray crystallographic studies of α-aryl substituted fosmidomycin analogues as inhibitors of mycobacterium tuberculosis 1-deoxy-d-xylulose 5-phosphate reductoisomerase

The natural antibiotic fosmidomycin acts via inhibition of 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXR), an essential enzyme in the non-mevalonate pathway of isoprenoid biosynthesis. Fosmidomycin is active on Mycobacterium tuberculosis DXR (MtDXR

ORGANOPHOSPHORIC DERIVATIVES USEFUL AS ANTI-PARASITIC AGENTS

The present invention relates to novel phosphonic acid compounds having the structural formula (I): wherein: (a) R is a group of 1 to 5 substituents independently selected from the group consisting of fluoro, chloro, bromo, C1-4 alkoxy, C1

Synthesis of α-aryl-substituted and conformationally restricted fosmidomycin analogues as promising antimalarials

Fosmidomycin represents a new antimalarial drug that acts by inhibition of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, an essential enzyme of the mevalonate-independent pathway of isoprenoid biosynthesis. This work describes the synthesis of a series

Synthesis of α-substituted fosmidomycin analogues as highly potent Plasmodium falciparum growth inhibitors

In view of the promising antimalarial activity of fosmidomycin or its N-acetyl homologue FR900098, the objective of this work was to investigate the influence of aromatic substituents in the α-position of the phosphonate moiety. The envisaged analogues we