7749-92-0

Basic information

• Product Name: Phosphonic acid, (3-oxo-1-phenylpropyl)-, diethyl ester
• CAS NO: 7749-92-0
• Molecular Formula: C13H19O4P
• Molecular Weight: 270.265
• Mol File: 7749-92-0.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Phosphonic acid, (3-oxo-1-phenylpropyl)-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonic acid, (3-oxo-1-phenylpropyl)-, diethyl ester(7749-92-0)
• EPA Substance Registry System: Phosphonic acid, (3-oxo-1-phenylpropyl)-, diethyl ester(7749-92-0)

Safety Data

• Hazardous Substances Data: 7749-92-0(Hazardous Substances Data)

Upstream product

• 14371-10-9 (E)-3-phenylpropenal 
• 25944-64-3 diethyl (1-phenylethenyl)phosphonate 
• 100-44-7 benzyl chloride 
• 100-51-6 benzyl alcohol 
• 100-52-7 benzaldehyde 
• 99365-10-3 N-(3-phenyl-2-propen-1-ylidene)isopropylamine 
• 114655-48-0 (E)-2-methyl-N-((E)-3-phenylallylidene)propan-2-amine 
• 1080-32-6 O,O-diethyl benzylphosphonate 
• 33973-22-7 (1-Phenyl-3-butenyl)phosphonsaeure-diethylester 
• 104-55-2 3-phenyl-propenal 
• 122-52-1 triethyl phosphite 

Downstream Products

• 942631-67-6 (E)-diethyl 3-(benzyloxy)imino-1-phenylpropylphosphonate 
• 884489-13-8 diethyl 3-(benzyloxy)imino-1-phenylpropylphosphonate 
• 884489-14-9 (3-benzyloxyamino-1-phenyl-propyl)-phosphonic acid diethyl ester 
• 1258145-94-6 C₁₀H₁₄NO₅P 
• 1258145-93-5 C₁₇H₂₀NO₅P 
• 1258145-92-4 C₂₁H₂₈NO₅P 
• 1258145-91-3 C₁₃H₁₉O₅P 
• 1012081-11-6 C₁₇H₂₆NO₄P 
• 1012081-07-0 C₁₆H₂₄NO₄P 
• 884489-17-2 diethyl [3-(N-hydroxyacetamido)-1-(phenyl)propyl]phosphonate 
• 852326-98-8 2,2-dimethyl-propionic acid [3-(acetyl-benzyloxy-amino)-1-phenyl-propyl]-(2,2-dimethyl-propionyloxymethoxy)-phosphinoyloxymethyl ester 
• 852326-97-7 2,2-dimethyl-propionic acid [3-(benzyloxy-formyl-amino)-1-phenyl-propyl]-(2,2-dimethyl-propionyloxymethoxy)-phosphinoyloxymethyl ester 
• 852326-95-5 [3-(benzyloxy-formyl-amino)-1-phenyl-propyl]-phosphonic acid diethyl ester 
• 852326-96-6 [3-(acetyl-benzyloxy-amino)-1-phenyl-propyl]-phosphonic acid diethyl ester 

Relevant articles and documents

Visible-Light-Promoted Decarboxylative Giese Reactions of α-Aryl Ethenylphosphonates and the Application in the Synthesis of Fosmidomycin Analogue

An approach for the synthesis of α-aryl alkylphosphonates based on visible-light photocatalytic Giese reaction of α-aryl vinylphosphonates with aliphatic carboxylic acids has been successfully developed. This protocol tolerates a wide range of functional

Synthesis of oxazinyl analogues of fosmidomycin using RCM methodology

Fosmidomycin is a promising antimalarial compound with a novel mode of action, the inhibition of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, a key enzyme in the biosynthesis of isoprenoids through the nonmevalonate pathway. This paper describes the synthesis of a series of analogues in which the hydroxamate moiety is incorporated in a ring structure, leaving the complexation with the enzyme up to the oxygen lone pairs instead of the free hydroxyl group. The antimalarial activities of the different analogues are currently under investigation. Georg Thieme Verlag Stuttgart.

Synthesis of α-aryl-substituted and conformationally restricted fosmidomycin analogues as promising antimalarials

Fosmidomycin represents a new antimalarial drug that acts by inhibition of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, an essential enzyme of the mevalonate-independent pathway of isoprenoid biosynthesis. This work describes the synthesis of a series