884490-75-9

Basic information

• Product Name: 5-{3-[2-oxo-5-(3-oxo-4-phenyl-but-1-enyl)-pyrrolidin-1-yl]-propyl}-thiophene-2-carboxylic acid methyl ester
• CAS NO: 884490-75-9
• Molecular Weight: 411.522
• Mol File: 884490-75-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-{3-[2-oxo-5-(3-oxo-4-phenyl-but-1-enyl)-pyrrolidin-1-yl]-propyl}-thiophene-2-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-{3-[2-oxo-5-(3-oxo-4-phenyl-but-1-enyl)-pyrrolidin-1-yl]-propyl}-thiophene-2-carboxylic acid methyl ester(884490-75-9)
• EPA Substance Registry System: 5-{3-[2-oxo-5-(3-oxo-4-phenyl-but-1-enyl)-pyrrolidin-1-yl]-propyl}-thiophene-2-carboxylic acid methyl ester(884490-75-9)

Safety Data

• Hazardous Substances Data: 884490-75-9(Hazardous Substances Data)

Upstream product

• 128899-30-9 (R)-5-(((tert-butyldimethylsilyl)oxy)methyl)pyrrolidin-2-one 
• 62224-19-5 5-bromo-2-thiophenecarboxylic acid methyl ester 
• 431990-32-8 5-{3-[2-(tert-butyl-dimethyl-silanyloxymethyl)-5-oxo-pyrrolidin-1-yl]-prop-1-ynyl}-thiophene-2-carboxylic acid methyl ester 
• 431990-31-7 (R)-5-(t-butyldimethylsiloxymethyl)-1-(2-propynyl)-2-pyrrolidinone 
• 431989-55-8 methyl 5-{3-[(2R)-2-(hydroxymethyl)-5-oxo-1-pyrrolidinyl]propyl}-2-thiophenecarboxylate 
• 107-06-2 1,2-dichloro-ethane 

Downstream Products

• 431990-03-3 5-{3-[2S-(3-hydroxy-4-phenyl-butyl)-5-oxo-pyrrolidin-1-yl]-propyl}-thiophene-2-carboxylic acid methyl ester 
• 431990-02-2 5-{3-[2-oxo-5S-(3-oxo-4-phenyl-butyl)-pyrrolidin-1-yl]-propyl}-thiophene-2-carboxylic acid methyl ester 

Relevant articles and documents

Discovery of highly selective EP4 receptor agonists that stimulate new bone formation and restore bone mass in ovariectomized rats

Heptanoic acid lactams, exemplified by 2, were identified as highly selective EP4 agonists via high throughput screening. Lead optimization led to the identification of lactams with a 30-fold increase in EP4 potency in vitro. Compounds demonstrated robust