884494-34-2

Usage

Uses

Used in Pharmaceutical Industry:
2-Ethynyl-5-fluoropyridine is used as a building block for the synthesis of pharmaceutical intermediates due to its unique structure and properties. It contributes to the development of new drugs and medicines.
Used in Agrochemical Industry:
In the agrochemical industry, 2-ethynyl-5-fluoropyridine is used as a starting material for the synthesis of agrochemicals, such as pesticides and herbicides, to improve crop protection and yield.
Used in Organic Synthesis:
2-Ethynyl-5-fluoropyridine is used as a reagent in organic synthesis, facilitating the formation of various compounds and contributing to the advancement of organic chemistry.
Used in the Synthesis of Heterocyclic Compounds:
As a pyridine derivative, 2-ethynyl-5-fluoropyridine is used in the synthesis of heterocyclic compounds, which are important in various fields, including pharmaceuticals, agrochemicals, and materials science.
Used in the Preparation of Bioactive Molecules:
2-Ethynyl-5-fluoropyridine serves as a starting material for the preparation of bioactive molecules, which have potential applications in drug discovery and development, as well as in other biological and chemical research areas.

Upstream product

• 904694-30-0 dimethylhydroxymethyl-5-fluoro-2-pyridylacetylene 
• 41404-58-4 2-bromo-5-fluoropyridine 
• 159870-80-1 5-fluoro-2-iodopyridine 
• 884494-40-0 2-(5-fluoro-2-pyridyl)ethynyl-trimethylsilane 
• 31181-88-1 5-fluoropicolinaldehyde 
• 90965-06-3 dimethyl 1-(1-diazo-2-oxopropyl)phosphonate 

Downstream Products

• 1410040-87-7 N-{2-[5-(5-fluoropyridin-2-yl)-1,2-oxazol-3-yl]ethyl}-5-methyl-2-(2H-1,2,3-triazol-2-yl)benzamide 

Relevant academic research and scientific papers

COMPOUNDS AND USES THEREOF

The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

2,4,6-Triaminopyrimidine as a Novel Hinge Binder in a Series of PI3Kδ Selective Inhibitors

Inhibition of phosphoinositide 3-kinase δ (PI3Kδ) is an appealing target for several hematological malignancies and inflammatory diseases. Herein, we describe the discovery and optimization of a series of propeller shaped PI3Kδ inhibitors comprising a novel triaminopyrimidine hinge binder. Combinations of electronic and structural strategies were employed to mitigate aldehyde oxidase mediated metabolism. This medicinal chemistry effort culminated in the identification of 52, a potent and highly selective inhibitor of PI3Kδ that demonstrates efficacy in a rat model of arthritis.

Efficient synthesis of 2-pyridylenynes and application in cobalt-catalysed benzannulation reactions

The cobalt-catalysed benzannulation of 2-pyridine-substituted enynes gave 2,3-bis(2-pyridyl)styrenes in moderate yields. The reaction with dibromomethane as well as diiodomethane generated the corresponding planar-chiral bispyridinium salts in good yields

NOVEL TRIAZOLE COMPOUNDS I

The present invention is concerned with novel triazole compounds of formula (I) wherein A, X, Y, Z, R1, R2, and R3 are as described herein, as well as pharmaceutically acceptable salts and esters thereof. The active compounds of present invention have affinity and selectivity for the GABA A α5 receptor. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.

TRIAZOLE DERIVATIVES AND THEIR USE FOR NEUROLOGICAL DISORDERS

The present invention is concerned with novel triazole compounds of formula (I) wherein A, X, Y, Z, R1, R2, and R3 are as described herein, as well as pharmaceutically acceptable salts and esters thereof. The active compounds of present invention have affinity and selectivity for the GABA A α5 receptor. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.

SUBSTITUTED ETHYNYL GOLD-NITROGENATED HETEROCYCLIC CARBENE COMPLEX AND ORGANIC ELECTROLUMINESCENT DEVICE USING SAME

The present invention provides a substituted ethynyl gold-nitrogen containing heterocyclic carbene complex represented by the general formula (1): wherein L represents a nitrogen containing heterocyclic carbene ligand; and X represents an alkyl group, a cycloalkyl group, an aryl group, an aralkyl group or a heterocyclic group; in which one or more hydrogen atoms on the carbon atom(s) of X may be replaced by a halogen atom, an alkyl group, a cycloalkyl group, an alkenyl group, an aryl group, an aralkyl group, an alkoxy group, an aryloxy group, a dialkylamino group, an acyl group or an arylcarbonyl group; and, when more than one hydrogen atom on the carbon atom(s) of X is replaced by the alkyl group, the alkenyl group, the aryl group, the aralkyl group, the alkoxy group, the aryloxy group, the dialkylamino group, the acyl group or the arylcarbonyl group, the adjacent groups may be bonded together to form a ring, a method for preparing the same, and an organic electroluminescent device comprising the substituted ethynyl gold-nitrogen containing heterocyclic carbene complex in at least one organic compound thin layer.