652160-72-0

Basic information

• Product Name: 2-BROMO-5-FLUORO-3-NITROPYRIDINE
• Synonyms: 2-BROMO-5-FLUORO-3-NITROPYRDINE;LogP
• CAS NO: 652160-72-0
• Molecular Formula: C₅H₂BrFN₂O₂
• Molecular Weight: 220.99
• Product Categories: Fluorine series
• Mol File: 652160-72-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 227℃
• Flash Point: 91℃
• Appearance: Pale orange/Solid
• Density: 1.923
• Vapor Pressure: 0.118mmHg at 25°C
• Refractive Index: 1.586
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -5.67±0.20(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 2-BROMO-5-FLUORO-3-NITROPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-5-FLUORO-3-NITROPYRIDINE(652160-72-0)
• EPA Substance Registry System: 2-BROMO-5-FLUORO-3-NITROPYRIDINE(652160-72-0)

Safety Data

• Hazardous Substances Data: 652160-72-0(Hazardous Substances Data)

Usage

General Description

2-Bromo-5-fluoro-3-nitropyridine is a chemical compound with the molecular formula C5H2BrFN2O2. The compound, recognized by its CAS number 884495-29-4, is commonly utilized in the field of chemistry, particularly in organic synthesis, where it serves as a building block for more complex molecules. 2-BROMO-5-FLUORO-3-NITROPYRIDINE is notable for its three distinct functional groups: a bromo group (Br), a fluoro group (F), and a nitro group (NO2) all attached to a pyridine ring, which is a six-membered aromatic heterocycle. This structure gives the compound certain chemical characteristics that can be exploited in synthesis reactions. Handling this chemical necessitates caution due to its potential for hazardous reactions. It should be stored and handled in controlled environments following appropriate safety guidelines.

InChI:InChI=1/C5H2BrFN2O2/c6-5-4(9(10)11)1-3(7)2-8-5/h1-2H

Upstream product

• 136888-20-5 5-fluoro-2-hydroxy-3-nitropyridine 
• 6628-77-9 6-methoxy-pyridin-3-ylamine 
• 51173-04-7 5-fluoro-2-methoxypyridine 
• 51173-05-8 5-fluoropyridin-2-ol 

Downstream Products

• 884494-99-9 2,6-dibromo-5-fluoropyridin-3-amine 
• 446284-56-6 4-fluoro-1H-pyrrolo[2,3-c]pyridine-7-carboxylic acid 
• 446284-50-0 4-fluoro-1H-pyrrolo[2,3-c]pyridine-7-carbonitrile 
• 1033202-51-5 5-fluoro-3-nitropyridine-2-carbonitrile 
• 1445856-76-7 (S)-N⁴-(5-cyclopropyl-1H-pyrazol-3-yl)-N²-(1-(6-fluoro-1-tosyl-1H-pyrrolo[3,2-b]pyridin-5-yl)ethyl)pyrimidine-2,4-diamine 
• 1445856-77-8 (R)-N⁴-(5-cyclopropyl-1H-pyrazol-3-yl)-N²-(1-(6-fluoro-1-tosyl-1H-pyrrolo[3,2-b]pyridin-5-yl)ethyl)pyrimidine-2,4-diamine 
• 1445856-75-6 N⁴-(5-cyclopropyl-1H-pyrazol-3-yl)-N²-(1-(6-fluoro-1-tosyl-1H-pyrrolo[3,2-b]pyridin-5-yl)ethyl)pyrimidine-2,4-diamine 
• 1445856-48-3 6-fluoro-1H-pyrrolo[3,2-b]pyridine-5-carbonitrile 
• 1445856-40-5 1-(6-fluoro-1-tosyl-1H-pyrrolo[3,2-b]pyridin-5-yl)ethanamine 
• 1445856-46-1 1-(6-fluoro-1-tosyl-1H-pyrrolo[3,2-b]pyridin-5-yl)ethanone oxime 
• 1445856-45-0 1-(6-fluoro-1-tosyl-1H-pyrrolo[3,2-b]pyridin-5-yl)ethanone 
• 1445856-44-9 6-fluoro-1-tosyl-1H-pyrrolo[3,2-b]pyridine-5-carbonitrile 
• 1445856-43-8 6-fluoro-1-tosyl-1H-pyrrolo[3,2-b]pyridine 4-oxide 
• 1445856-42-7 6-fluoro-1-tosyl-1H-pyrrolo[3,2-b]pyridine 

Relevant articles and documents

Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment. 12. Structure-activity relationships associated with 4-fluoro-6-azaindole derivatives leading to the identification of 1-(4-benzoylpiperazin-1-yl)-2-(4- fluoro-7-[1,2,3]triazol-1-yl-1H-

A series of highly potent HIV-1 attachment inhibitors with 4-fluoro-6-azaindole core heterocycles that target the viral envelope protein gp120 has been prepared. Substitution in the 7-position of the azaindole core with amides (12a,b), C-linked heterocycl

Prodrugs of piperazine and substituted piperidine antiviral agents

This invention provides for prodrug Compounds I, pharmaceutical compositions thereof, and their use in treating HIV infection. wherein: X is C or N with the proviso that when X is N, R1 does not exist; W is C or N with the proviso that when W is N, R2 does not exist; V is C; E is hydrogen or a pharmaceutically acceptable salt thereof; and Y is selected from the group consisting of Also, this invention provides for intermediate Compounds II useful in making prodrug Compounds I. wherein: L and M are independently selected from the group consisting of C1-C6 alkyl, phenyl, benzyl, trialkylsilyl, -2,2,2-trichloroethoxy and 2-trimethylsilylethoxy.

Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives

This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.