884511-35-7Relevant academic research and scientific papers
Hydroxytriamides as potent γ-secretase inhibitors
Prasad,Noonan, Jeffrey W.,Sloan, Charles P.,Lau, Wai,Vig, Shikha,Parker, Michael F.,Smith, David W.,Hansel, Steven B.,Polson, Craig T.,Barten, Donna M.,Felsenstein, Kevin M.,Roberts, Susan B.
, p. 1917 - 1921 (2004)
Using a cell-based assay, we have identified optimal residues and key recognition elements necessary for inhibition of γ-secretase. An (S)-hydroxy group or 3,5-difluorophenylacetyl group at the amino terminus and N-methyltertiary amide moiety at the carbo
