884541-34-8

Basic information

• Product Name: 6-amino-5-bromo-3,4-dihydronaphthalen-1(2H)-one
• Synonyms: 6-amino-5-bromo-3,4-dihydronaphthalen-1(2H)-one;6-amino-5-bromo-1,2,3,4-tetrahydronaphthalen-1-ol
• CAS NO: 884541-34-8
• Molecular Formula: C₁₀H₁₀BrNO
• Molecular Weight: 240.0965
• Mol File: 884541-34-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-amino-5-bromo-3,4-dihydronaphthalen-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-amino-5-bromo-3,4-dihydronaphthalen-1(2H)-one(884541-34-8)
• EPA Substance Registry System: 6-amino-5-bromo-3,4-dihydronaphthalen-1(2H)-one(884541-34-8)

Safety Data

• Hazardous Substances Data: 884541-34-8(Hazardous Substances Data)

Upstream product

• 3470-53-9 6-amino-1-tetralone 

Relevant articles and documents

Fast and efficient bromination of aromatic compounds with ammonium bromide and Oxone

A highly efficient, rapid and regioselective protocol was developed for the ring bromination of aromatic compounds under mild conditions with ammonium bromide as a source of bromine source and Oxone (potassium peroxysulfate) as an oxidant. No metal catalyst or acidic additive is required. A variety of aromatic compounds, including methoxy, hydroxy, amino, and alkyl arenes, reacted smoothly to give the corresponding monobrominated products in good to excellent yields in very short reaction times. Moreover, dibromination of deactivated anilines to give the corresponding dibromides proceeded in high yields. Interestingly, 1-(2-naphthyl)ethanone provided a ring-brominated product. Georg Thieme Verlag Stuttgart . New York.

Titanium(IV) chloride promoted syntheses of new imidazo[1,2-a]pyridine derivatives under microwave conditions

A new method is described for the synthesis of imidazo[1,2-a]pyridine derivatives from the reaction of 2-aminopyridines with α-haloketones. The critical reagent is titanium(IV) chloride, which appears to serve as a strong dehydrating agent to promote formation of putative Schiff base intermediates, which cyclize subsequently to form the products. The reactions were performed rapidly under microwave conditions. Multiple reaction conditions were evaluated, including reaction temperature, solvent and other Lewis acids. Various combinations of substitution patterns in both the α-haloketone and 2-aminopyridine substrates were examined to evaluate the scope of the reaction. The reaction is quite sensitive to substituents in both substrates, especially those with basicity or coordination ability. Georg Thieme Verlag Stuttgart.