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Usage

Uses

Used in Pharmaceutical Synthesis:
1(2H)-Pyridinecarboxylic acid, 3,4-dihydro-4-oxo-2-[4-(trifluoromethyl)phenyl]-, phenylmethyl ester is used as a building block for the synthesis of pharmaceuticals. Its unique structure allows it to be a valuable component in the development of new drugs.
Used in Agrochemical Synthesis:
In the agrochemical industry, 1(2H)-Pyridinecarboxylic acid, 3,4-dihydro-4-oxo-2-[4-(trifluoromethyl)phenyl]-, phenylmethyl ester is used as a building block for the synthesis of various agrochemicals, contributing to the development of effective products for agricultural applications.
Used in Medicinal Chemistry Research:
1(2H)-Pyridinecarboxylic acid, 3,4-dihydro-4-oxo-2-[4-(trifluoromethyl)phenyl]-, phenylmethyl ester is also used as a tool compound in medicinal chemistry research. Its potential therapeutic properties, including anti-inflammatory and analgesic effects, make it a promising candidate for further investigation and development in the field of medicine.
Used in Therapeutic Applications:
Due to its potential therapeutic properties, 1(2H)-Pyridinecarboxylic acid, 3,4-dihydro-4-oxo-2-[4-(trifluoromethyl)phenyl]-, phenylmethyl ester is being studied for its use in the development of treatments for various conditions, particularly those that may benefit from its anti-inflammatory and analgesic effects.

Upstream product

• 620-08-6 4-methoxypyridine 
• 501-53-1 benzyl chloroformate 
• 402-51-7 4-(trifluoromethyl)phenylmagnesium bromide 
• 402-43-7 p-trifluoromethylphenyl bromide 

Relevant academic research and scientific papers

Fluorinated piperidine acetic acids as γ-secretase modulators

We report herein a novel series of difluoropiperidine acetic acids as modulators of γ-secretase. Synthesis of 2-aryl-3,3-difluoropiperidine analogs was facilitated by a unique and selective β-difluorination with Selectfluor. Compounds 1f and 2c were selec

SILYLATED PIPERIDINE DERIVATIVES

Compounds of formula I: I wherein at least one of R4 and R5 comprises Si(R6)3 as a substituent selectively attenuate production of A?(1-42) and hence find use in treatment of Alzheimer's disease and related conditions.

DIFLUORINATED PIPERIDINES FOR TREATMENT OF ALZHEIMER'S DISEASE AND RELATED CONDITIONS

Compounds of formula (I). Selectively inhibit production of Aβ(1-42) and hence find use in treatment of diseases associated with deposition of β-amyloid in the brain.

Synthesis of C2-symmetric trans-2,6-diarylpiperidinones via aryl cuprate addition: an unexpected stereochemical outcome

An efficient procedure for the preparation of trans-2,6-diaryl piperidinones has been developed. Addition of aryl Grignard reagents to 2-aryl dihydropyridones under catalytic copper promoted conditions generates the trans isomer exclusively, an unprecedented stereochemical event. The X-ray structures of both starting material and product have been solved and shed light on the steric constraints and substrate geometry leading to the observed product. The reaction conditions tolerate a variety of aromatic nucleophiles to generate C2-symmetric products in good overall yields.

PIPERIDINE DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE

Compounds of formula (I) modulate the activity of gamma secretase and hence find use in treatment or prevention of Alzheimer's disease and related conditions.

PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER’S DISEASE

Compounds of formula (I) are modulators of gamma-secretase, and hence are useful in treatment of Alzheimer’s disease.

PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE

Compounds of formula (I), selectively inhibit production of Aβ (1-42) and hence are useful in treatment or prevention of disease assocaited with deposition of β -amyloid in the brain.