884607-88-9Relevant articles and documents
Light absorption and hole-transport properties of copper corroles: From aggregates to a liquid crystal mesophase
Gao, Di,Andeme Edzang, Judicaelle,Diallo, Abdou Karim,Dutronc, Thibault,Balaban, Teodor Silviu,Videlot-Ackermann, Christine,Terazzi, Emmanuel,Canard, Gabriel
, p. 7140 - 7146 (2015)
The synthesis of the corrole-based liquid crystal phase CorLC is described together with its full characterization using a combination of Polarised Optical Microscopy (POM), ThermoGravimetric Analysis (TGA), Differential Scanning Calorimetry (DSC) measure
One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA
Atochina-Vasserman, Elena N.,Billingsley, Margaret M.,Huang, Ning,Kim, Kyunghee,Liu, Matthew,Maurya, Devendra S.,Mitchell, Michael J.,Ni, Houping,Ona, Nathan,Percec, Virgil,Pochan, Darrin J.,Shahnawaz, Hamna,Weissman, Drew,Xiao, Qi,Zhang, Dapeng
, p. 12315 - 12327 (2021/08/20)
Efficient viral or nonviral delivery of nucleic acids is the key step of genetic nanomedicine. Both viral and synthetic vectors have been successfully employed for genetic delivery with recent examples being DNA, adenoviral, and mRNA-based Covid-19 vaccines. Viral vectors can be target specific and very efficient but can also mediate severe immune response, cell toxicity, and mutations. Four-component lipid nanoparticles (LNPs) containing ionizable lipids, phospholipids, cholesterol for mechanical properties, and PEG-conjugated lipid for stability represent the current leading nonviral vectors for mRNA. However, the segregation of the neutral ionizable lipid as droplets in the core of the LNP, the "PEG dilemma", and the stability at only very low temperatures limit their efficiency. Here, we report the development of a one-component multifunctional ionizable amphiphilic Janus dendrimer (IAJD) delivery system for mRNA that exhibits high activity at a low concentration of ionizable amines organized in a sequence-defined arrangement. Six libraries containing 54 sequence-defined IAJDs were synthesized by an accelerated modular-orthogonal methodology and coassembled with mRNA into dendrimersome nanoparticles (DNPs) by a simple injection method rather than by the complex microfluidic technology often used for LNPs. Forty four (81%) showed activity in vitro and 31 (57%) in vivo. Some, exhibiting organ specificity, are stable at 5 °C and demonstrated higher transfection efficiency than positive control experiments in vitro and in vivo. Aside from practical applications, this proof of concept will help elucidate the mechanisms of packaging and release of mRNA from DNPs as a function of ionizable amine concentration, their sequence, and constitutional isomerism of IAJDs.
POLYCATENAR LIGANDS AND HYBRID NANOPARTICLES MADE THEREFROM
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Page/Page column 35; 38; 39, (2017/10/13)
Described herein are polycatenar ligand compounds and their use in the production of hybrid nanoparticles, typically nanocrystals. The present disclosure also relates to films containing the hybrid nanoparticles described herein and their use.
Polycatenar Ligand Control of the Synthesis and Self-Assembly of Colloidal Nanocrystals
Diroll, Benjamin T.,Jishkariani, Davit,Cargnello, Matteo,Murray, Christopher B.,Donnio, Bertrand
, p. 10508 - 10515 (2016/09/04)
Hydrophobic colloidal nanocrystals are typically synthesized and manipulated with commercially available ligands, and surface functionalization is therefore typically limited to a small number of molecules. Here, we report the use of polycatenar ligands d
Self-Assembly of Amphiphilic Janus Dendrimers into Mechanically Robust Supramolecular Hydrogels for Sustained Drug Release
Nummelin, Sami,Liljestr?m, Ville,Saarikoski, Eve,Ropponen, Jarmo,Nyk?nen, Antti,Linko, Veikko,Sepp?l?, Jukka,Hirvonen, Jouni,Ikkala, Olli,Bimbo, Luis M.,Kostiainen, Mauri A.
, p. 14433 - 14439 (2015/10/05)
Compounds that can gelate aqueous solutions offer an intriguing toolbox to create functional hydrogel materials for biomedical applications. Amphiphilic Janus dendrimers with low molecular weights can readily form self-assembled fibers at very low mass pr
