88465-93-4

Upstream product

• 38131-57-6 2-benzenesulfonylmethacrylic acid methyl ester 
• 80-62-6 methacrylic acid methyl ester 
• 4224-69-5 methyl 2-(bromomethyl)propenoate 
• 17376-04-4 2-phenethyl iodide 
• 3708-34-7 2-(3-phenylpropyl)-malonic acid dimethyl ester 
• 501-52-0 3-Phenylpropionic acid 
• 476469-28-0 2,2-dimethyl-5-(3-phenyl-propyl)-[1,3]dioxane-4,6-dione 

Downstream Products

• 113592-38-4 2-[(1-Benzyloxycarbonylamino-ethyl)-methoxy-phosphinoylmethyl]-5-phenyl-pentanoic acid methyl ester 
• 113592-36-2 1-Aminoethyl-[2-carboxy-5-phenyl-1-n-pentyl]-phosphinic acid 

Relevant academic research and scientific papers

Catalyst-Free Deaminative Functionalizations of Primary Amines by Photoinduced Single-Electron Transfer

The use of pyridinium-activated primary amines as photoactive functional groups for deaminative generation of alkyl radicals under catalyst-free conditions is described. By taking advantage of the visible light absorptivity of electron donor–acceptor complexes between Katritzky pyridinium salts and either Hantzsch ester or Et3N, photoinduced single-electron transfer could be initiated in the absence of a photocatalyst. This general reactivity platform has been applied to deaminative alkylation (Giese), allylation, vinylation, alkynylation, thioetherification, and hydrodeamination reactions. The mild conditions are amenable to a diverse range of primary and secondary alkyl pyridiniums and demonstrate broad functional group tolerance.

Palladium-Catalyzed Electrochemical Allylic Alkylation between Alkyl and Allylic Halides in Aqueous Solution

A new route for the direct cross-coupling of alkyl and allylic halides using electrochemical technique has been developed in aqueous media under air. Catalyzed by Pd(OAc)2, the Zn-mediated allylic alkylations proceed smoothly between a full range of alkyl halides (primary, secondary, and tertiary) and substituted allylic halides. Protection-deprotection of acidic hydrogen in the substrates is avoided.

Facile synthesis of α-substituted acrylate esters

Treatment of 5-monosubstituted Meldrum's acids with dimethylmethyleneimmonium iodide (Eschenmoser's iodide salt) in methanol gives α-substituted acrylate methyl esters in good yields. Easy access to 5-monosubstituted Meldrum's acids allowed us to synthesize a wide variety of α-substituted acrylate methyl esters. The reaction conditions are mild and tolerate many functional groups commonly used in organic synthesis; thus, this new method has potential as an alternative to conventional preparative methods for α-substituted acrylate esters.

Novel antibacterial agents and potentiators of carbapenem antibiotics

New 3-(1-aminoalkylphosphinyl)-(2-substituted)propionic acids are described which display antibacterial activity and potentiate carbapenem antibiotics.

Substituted oxiranecarboxylic acids, their use and medicaments containing them

Substituted oxiranecarboxylic acids of the formula STR1 wherein R1 denotes a hydrogen atom (--H), a halogen atom, a hydroxylroup, a lower alkyl group, a lower alkoxy group or a trifluoromethyl group, R2 has one of the meanings of Rs