88466-69-7Relevant academic research and scientific papers
Cobalt-Catalyzed Highly Regioselective Three-Component Arylcarboxylation of Acrylate with Aryl Bromides and Carbon Dioxide
Hang, Wei,Liang, Nianjie,Liu, Yuzhou,Xi, Chanjuan
, p. 4941 - 4946 (2021/10/30)
Cobalt-catalyzed regioselective three-component arylcarboxylation of acrylate with aryl bromides and carbon dioxide has been developed. The reaction is carried out by using cobalt chloride as a precatalyst and zinc powder as a reducing reagent under CO2 (1 atm) at 40 °C. A range of aryl bromides are used for this reaction, leading to a series of valuable carboxylic acids with high regioselectivity and functional-group compatibility. Mechanistic experiments and DFT calculations indicate that this arylcarboxylation reaction involves the reaction of CO2 with a cobalt enolate intermediate to form the C?C bond.
Asymmetric Michael addition of malonic diesters to acrylates by phase-transfer catalysis toward the construction of quaternary stereogenic α-carbons
Odanaka, Yuki,Kanemitsu, Takuya,Iwasaki, Kanako,Mochizuki, Yukiko,Miyazaki, Michiko,Nagata, Kazuhiro,Kato, Masaru,Itoh, Takashi
supporting information, p. 209 - 219 (2018/12/11)
A highly enantioselective construction of an all-carbon quaternary stereogenic center at the α-position of malonic diesters has been achieved by Michael addition using phase-transfer catalysis. The reaction of α-monosubstituted malonates with acrylates in
Enantioselective α-Benzoyloxylation of Malonic Diesters by Phase-Transfer Catalysis
Kanemitsu, Takuya,Sato, Miho,Yoshida, Miyuki,Ozasa, Eisuke,Miyazaki, Michiko,Odanaka, Yuki,Nagata, Kazuhiro,Itoh, Takashi
supporting information, p. 5484 - 5487 (2016/11/17)
A highly enantioselective α-benzoyloxylation of malonic diester has been achieved by phase-transfer catalysis. The reaction of α-monosubstituted tert-butyl methyl malonate with benzoyl peroxide in the presence of aqueous KOH and N-(9-anthracenylmethyl)cinchoninium chloride afforded the corresponding α,α-disubstituted products in generally excellent chemical yields (up to 99% yield) with high enantioselectivities (up to 96% ee). In addition, the utility of this methodology was exhibited by the synthesis of a mineralocorticoid receptor antagonist.
AN EASY SYNTHESIS OF MONOMETHYL MALONATE DERIVATIVES
Matoba, Katsuhide,Yamazaki, Takao
, p. 2955 - 2956 (2007/10/02)
Monomethyl malonates (IIIa-c and Va) were synthesized from Meldrum's acid (Ia) by treating with an excess of diazomethane in the corresponding alcohols and piperidine, respectively, in quantitative yields.In a similar manner, 5-p-chlorobenzyl Meldrum's acid (Ib) afforded the corresponding monomethyl malonate derivatives (IIIe, f, and Vb).The mechanism proposed for this reaction is described.KEYWORDS - Meldrum's acid; monomethyl malonate; half ester; ketene ester; 4,6-dioxo-1,3-dioxane
